19 Harley St, London, W1G 9QJ, UK
We are London's Top Spine Clinic

Wnt3 and Gata4 regulate axon regeneration in adult mouse DRG neurons.


Icon for Elsevier Science Related Articles

Wnt3 and Gata4 regulate axon regeneration in adult mouse DRG neurons.

Biochem Biophys Res Commun. 2018 05 05;499(2):246-252

Authors: Duan RS, Liu PP, Xi F, Wang WH, Tang GB, Wang RY, Saijilafu, Liu CM

Neurons in the adult central nervous system (CNS) have a poor intrinsic axon growth potential after injury, but the underlying mechanisms are largely unknown. Wingless-related mouse mammary tumor virus integration site (WNT) family members regulate neural stem cell proliferation, axon tract and forebrain development in the nervous system. Here we report that Wnt3 is an important modulator of axon regeneration. Downregulation or overexpression of Wnt3 in adult dorsal root ganglion (DRG) neurons enhances or inhibits their axon regeneration ability respectively in vitro and in vivo. Especially, we show that Wnt3 modulates axon regeneration by repressing mRNA translation of the important transcription factor Gata4 via binding to the three prime untranslated region (3’UTR). Downregulation of Gata4 could restore the phenotype exhibited by Wnt3 downregulation in DRG neurons. Taken together, these data indicate that Wnt3 is a key intrinsic regulator of axon growth ability of the nervous system.

PMID: 29567480 [PubMed – indexed for MEDLINE]


Share to care...

Share on facebook
Share on twitter
Share on pinterest
Share on google
Share on linkedin
Share on skype

What we do...

The Harley Street Hospital


What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

We treat all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

What our patients say about us ......

Cervical Epidural

I was really impressed by the diagnosis and treatment that I received. My condition has been considerably improved. John W. You May Also Like:Acute nuclear

Read More »