Whether or not innate immune along with genetic issue are concerned in leukemic arthritis?: A case report and overview of the literature.
Medication (Baltimore). 2018 Feb;97(7):e9919
Authors: Xu D, Xu G, Lin J
We report a case of leukemic arthritis (LA) of monocytic differentiation, which offered with spondyloarthritis-like signs and a constructive human leukocyte antigen-B27, and talk about its potential mechanisms.The affected person was admitted due to ache in her proper knee and decrease again for 18 months. Magnetic resonance imaging confirmed diffuse hyperintense sign within the bilateral liac bones and bone marrow edema and synovitis in the proper knee.The analysis of acute monocytic leukemia and LA have been concluded by bone marrow aspiration and move cytometry of the synovial fluid.The affected person had poor response to nonsteroidal anti-inflammatory medication. One week after she obtained chemotherapy, the signs have been dramatically relieved.For five-year follow-up, she acquired medical remission with out struggling ache of the proper knee and the decrease again.Leukemic arthritis is a uncommon manifestation of leukemia with unknown mechanism and could be the preliminary presentation of leukemia. The issue whether or not irregular immune response of the neoplasitc monocytes along with hereditary components contribute to the pathogenesis of LA in grownup is raised from this case, which value additional analysis.
PMID: 29443770 [PubMed – indexed for MEDLINE]