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Vertebral osteoporosis: perfused animal cadaver model for testing new vertebroplastic agents

STUDY DESIGN: Experimental study. OBJECTIVE: It was aimed to establish a cadaver model to imitate osteoporotic perfused vertebral bone and to allow for transpedicular transfer of bone cement and various new materials into vertebrae. The model was perfused to simulate vertebroplasty in the presence of transvertebral blood flow. SUMMARY OF BACKGROUND DATA: The injection of bone cement into vertebrae bears the risk of irreversible discharge of material into the venous system of the spinal canal. The bovine cadaver model studied allows visual studies of material distribution in a vertebral bone, the potential spill-out of material, and quantification of washout and disintegration phenomena. METHODS: Thoracic and lumbar vertebrae from 1-year-old calves were cut transversally into 5 mm slices, macerated, and decalcified. The softened bone slices were compressed between 2 transparent plastic discs. A standard vertebroplasty cannula (outer diameter 3.5 mm, inner diameter 2.5 mm) was inserted into the vertebral body via the pedicle to transfer the different vertebroplasty materials. Arterial blood flow was simulated by means of liquid irrigation via 2 needles in the ventral part of the vertebral body slice. Metal powder was mixed with the solution to indicate the blood flow in the bone. The model was evaluated with the vertebroplasty cement polymethylmethacrylate. RESULTS: The model permitted visualization of the insertion and distribution of vertebroplasty materials. Liquid bone cement was effused into the spinal canal as in the clinical situation. Higher modulus cement acted in the same way as in clinical vertebroplasty. Rigid vertebroplasty agents led to trabecular fractures and stable mechanical interactions with the bone and eventually moved dorsal bone fragments into the spinal canal. Sedimentation of the metal powder indicated regions of perfusion. CONCLUSION: The model simulated the clinical behavior of liquid and higher modulus vertebroplasty agents in the presence of blood flow. It enabled safe ex vivo testing of the mechanical and physical properties of alternative vertebroplasty materials under flow conditions

Keywords : Animals,blood,Bone Cements,Cadaver,Cattle,Disease Models,Animal,Germany,Kyphoplasty,Lumbar Vertebrae,methods,Needles,Osteoporosis,Spinal Canal,Spine,surgery,Thoracic Vertebrae,Vertebroplasty,, Osteoporosis,Perfused,Animal,Cadaver,Model, meralgia paresthetica patient uk

Date of Publication : 2010 Dec 1

Authors : Hoell T;Huschak G;Beier A;Holzhausen HJ;Meisel HJ;Emmrich F;

Organisation : Spine Center Baden, Mittelbaden Hospital, Baden-Baden, Germany. Hoell@klinikum-mittelbaden.de

Journal of Publication : Spine (Phila Pa 1976 )

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21102272

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