[Vertebral fractures in children with Type I Osteogenesis imperfecta].
Rev Chil Pediatr. 2017 Jun;88(three):348-353
Authors: Sepúlveda AM, Terrazas CV, Sáez J, Reyes ML
Osteogenesis imperfecta (OI) is an hereditary illness affecting conective tissue, primarily related to development retardation and pathological fractures. OI kind I (OI kind I), is the mildest, most frequently, and homogeneous in its fenotype. Vertebral fractures are probably the most vital issues, related to skeletical and cardiopulmonary morbidity.
OBJECTIVES: To characterize clinically a cohort of youngsters with OI kind I.
PATIENTS AND METHODS: A cohort of OI kind I kids youthful than 20 yr outdated was evaluated. Demographic, medical, biochemical and radiological knowledge had been registered.
RESULTS: Sixty seven sufferers had been included, 55% male, 69% resident within the Metropolitan Area. The imply age of diagnose was 2.9 years, 70% introduced vertebral fractures on follow-up, principally thoracic, and 50% earlier than the age of 5 years. Fifty proportion introduced vertebral fractures at diagnose, which was concerning the age of 5 years. Bone metabolic parameters had been within the regular vary, with out vital change for the time being of vertebral fractures. Calcium consumption was discovered to be beneath American Academy of Pediatrics suggestions on the time of the primary fracture.
CONCLUSIONS: On this research OI kind I has an early diagnose, and vertebral fractures present a excessive incidence, principally in toddlers. Calcium consumption was discovered to be beneath reccomended values, and must be carefully supervised in these sufferers.
PMID: 28737193 [PubMed – indexed for MEDLINE]