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Vertebral End Plate Perforation for Intervertebral Disc Height Preservation After Single Level Lumbar Discectomy: A Randomized Controlled Trial.

Vertebral End Plate Perforation for Intervertebral Disc Height Preservation After Single Level Lumbar Discectomy: A Randomized Controlled Trial.

J Spinal Disord Tech. 2015 Jun 18;

Authors: Vodi?ar M, Košak R, Gorenšek M, Korez R, Vrtovec T, Koder J, Antoli? V, Vengust R

STUDY DESIGN: Pilot single-centre, stratified, prospective, randomized, double-blinded, parallel-group, controlled study.
OBJECTIVE: To determine whether vertebral end-plate perforation after lumbar discectomy causes annulus reparation and intervertebral disc volume restoration. To determine that after six months there would be no clinical differences between the control and study group.
SUMMARY OF BACKGROUND DATA: Low back pain is the commonest long-term complication after lumbar discectomy. It is mainly caused by intervertebral disc space loss, which promotes progressive degeneration. This is the first study to test the efficiency of a previously described method (vertebral end-plate perforation) that should advocate for annulus fibrosus reparation and disc space restoration.
METHODS: We selected 30 eligible patients according to inclusion and exclusion criteria and randomly assigned them to the control (no end-plate perforation) or study (end-plate perforation) group. Each patient was evaluated in 5 different periods, where data was collected (preoperative and six months follow up MRI and functional outcome data (VAS back, VAS legs, Oswestry disability questionnaire). Intervertebral space volume (ISV) and height (ISH) were measured form the MRI images. Statistical analysis was performed using paired t-test and linear regression. P<0.05 was considered statistically significant.
RESULTS: We found no statistically significant difference between the control group and the study group concerning ISV (P=0.6808) and ISH (P=0.8981) six months after surgery. No statistically significant differences were found between ODI, VAS back and VAS legs after six months between the two groups, however there were statistically significant differences between these parameters in different time periods. Correlation between the volume of disc tissue removed and preoperative versus postoperative difference in ISV was statistically significant (P=0.0020).
CONCLUSIONS: The present study showed positive correlation between the volume of removed disc tissue and decrease in postoperative ISV and ISH. There were no statistically significant differences in ISV and ISH between the group with end-plate perforation and the control group six months after lumbar discectomy. Clinical outcome and disability were significantly improved in both groups three and six months after surgery.

PMID: 26091264 [PubMed – as supplied by publisher]

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