Vertebral bone attenuation on low-dose chest CT: quantitative volumetric evaluation for bone fragility evaluation.
Osteoporos Int. 2017 Jan;28(1):329-338
Authors: Kim YW, Kim JH, Yoon SH, Lee JH, Lee CH, Shin CS, Park YS
This examine evaluated using low-dose chest computed tomography (LDCT) for detecting bone fragility. LDCT-measured vertebral bone attenuation by volumetric strategies confirmed good correlation with bone mineral density (BMD) measured by dual-energy x-ray absorptiometry (DXA, and good diagnostic efficiency for figuring out osteoporosis and compression fractures. The outcomes of this examine recommend the feasibility of acquiring complete info on bone well being in topics present process LDCT.
INTRODUCTION: Osteoporosis is a prevalent however underdiagnosed illness that will increase fracture danger. This examine evaluated the utility of vertebral attenuation derived from low-dose chest computed tomography (LDCT) in comparison with dual-energy x-ray absorptiometry (DXA) for detecting bone fragility.
METHODS: A complete of 232 topics (78 males and 154 girls) aged above 50 years who underwent each LDCT and DXA inside 30 days had been evaluated. LDCT-measured bone attenuation in Hounsfield models (HU) of 4 vertebrae (T4, T7, T10, and L1) was evaluated utilizing volumetric strategies for correlation with DXA-measured bone mineral density (BMD) and for the prognosis of compression fractures, osteoporosis, and low BMD (osteoporosis or osteopenia) in women and men, with DXA measurements because the reference normal.
RESULTS: The typical attenuation of the 4 vertebrae confirmed sturdy correlation with DXA-measured BMD of the lumbar backbone (r?=?Zero.726, p?<?Zero.05). In receiver-operating attribute (ROC) analyses, the realm beneath the curve (AUC) throughout LDCT-measured thresholds of the typical attenuation to tell apart compression fractures was Zero.827, and a threshold of 129.5 HU yielded 90.9 % sensitivity and 64.four % specificity. Equally, common attenuation confirmed excessive AUCs and good diagnostic efficiency for detecting osteoporosis and low BMD in each women and men. Amongst 44 topics with compression fractures, the typical bone attenuation confirmed sturdy adverse correlation with each the worst fracture grade (r?=?-Zero.525, p?<?Zero.05) and cumulative fracture grade rating (r?=?-Zero.633, p?<?Zero.05).
CONCLUSION: LDCT-measured bone attenuation by volumetric strategies confirmed good correlation with BMD measured by DXA and good diagnostic efficiency for figuring out bone fragility.
PMID: 27480628 [PubMed – indexed for MEDLINE]