Vertebral physique morphology is related to incident lumbar vertebral fracture in postmenopausal girls. The OFELY research.
Osteoporos Int. 2016 Aug;27(eight):2507-13
Authors: Roux JP, Belghali S, Wegrzyn J, Rendu ES, Chapurlat R
UNLABELLED: We examine the predictive function of vertebral anterior cortical curvature and top heterogeneity within the incidence of vertebral fractures in postmenopausal girls. Girls who will fracture had shorter vertebral top, higher heterogeneity of top than those that won’t fracture, and their anterior vertebral physique edge was much less concave.
INTRODUCTION: Vertebral morphology has been demonstrated to be related to additional danger of fracture. The goal of this research was to research vertebral anterior cortical curvature (Ct.curv) and vertebral top heterogeneity in postmenopausal girls earlier than the incidence of a vertebral fracture.
METHODS: This case-control research included 29 postmenopausal girls who’ve underwent incident lumbar vertebral fractures (imply age 71?±?9 years, imply time to fractures 9?±?four years), age-matched with 57 controls. From lateral X-rays of lumbar backbone radiographs (T12 to L4), the next parameters had been measured: (1) the posterior, center, and anterior vertebral heights; (2) the heterogeneity of heights evaluated by the coefficient of variation of those three variables; (three) antero-posterior width, a 2D estimator of cross-sectional space; and (four) Ct.curv.
RESULTS: Imply vertebral heights had been considerably decrease amongst girls who fractured than in controls (p?<?zero.05). The anterior and center heights had been considerably decrease at L4 and L3 ranges in fracture group (p?=?zero.02). The heterogeneity of vertebral top was considerably higher within the fracture group (p?=?zero.003). As well as, fractured sufferers had a considerably greater Ct.curv on L3 (p?=?zero.04). After adjustment for bone mineral density (BMD), solely the heterogeneity of vertebral top remained vital (p?=?zero.zero05).
CONCLUSION: The present case-control research confirmed the affiliation between vertebral top and incidence of future vertebral fracture in postmenopausal girls. The vertebrae with the smallest Ct.curv tended to fracture much less typically, and the heterogeneity of vertebral heights was related to future fracture independently of BMD. A further validation in a potential research could be wanted to substantiate these preliminary outcomes.
PMID: 26957288 [PubMed – indexed for MEDLINE]