Vagus nerve stimulation inhibits trigeminal nociception in a rodent mannequin of episodic migraine.
Ache Rep. 2017 Nov;2(6):e628
Authors: Hawkins JL, Cornelison LE, Blankenship BA, Durham PL
Introduction: Though neck muscle rigidity is taken into account a danger issue for migraine, pungent odors can act as a set off to provoke an assault in sensitized people. Though noninvasive vagus nerve stimulation (nVNS) is now an permitted remedy for power migraine, the way it features to inhibit trigeminal nociception in an episodic migraine mannequin is just not recognized.
Goals: The aims of this research had been to find out if nVNS might inhibit trigeminal nociception in a novel mannequin of episodic migraine and examine modifications within the expression of proteins implicated in peripheral and central sensitization.
Strategies: Sprague-Dawley male rats had been injected with an inflammatory agent within the trapezius muscle earlier than publicity to pungent unstable compounds, which was used to provoke trigeminal nociceptor activation. The vagus nerve was stimulated transdermally by a 1-ms pulse of 5 kHz sine waves, repeated at 25 Hz for two minutes. Nocifensive head withdrawal response to von Frey filaments was decided and immunoreactive protein ranges within the spinal wire and trigeminal ganglion (TG) had been investigated.
Outcomes: Publicity to the pungent odor considerably elevated the variety of nocifensive withdrawals in response to mechanical stimulation of sensitized TG neurons mediated by neck muscle irritation. Noninvasive vagus nerve stimulation inhibited nociception and repressed elevated ranges of P-ERK in TG, Iba1 in microglia, and GFAP in astrocytes from sensitized animals uncovered to the pungent odor.
Conclusion: Our findings reveal that nVNS inhibits mechanical nociception and represses expression of proteins related to peripheral and central sensitization of trigeminal neurons in a novel rodent mannequin of episodic migraine.
PMID: 29392242 [PubMed]