Menu
Menu
19 Harley St, London, W1G 9QJ, UK
We are London's Top Spine Clinic

Use of Bone Morphogenetic Protein-2 in Vertebral Column Tumor Surgical procedure: A Nationwide Investigation.

Related Articles

Use of Bone Morphogenetic Protein-2 in Vertebral Column Tumor Surgical procedure: A Nationwide Investigation.

World Neurosurg. 2018 Could 04;:

Authors: De la Garza Ramos R, Nakhla J, Echt M, Gelfand Y, Altschul DJ, Cho W, Kinon MD, Yassari R

Summary
OBJECTIVE: To report the speed of bone morphogenetic protein-2 (BMP-2) use in vertebral column tumor surgical procedure.
METHODS: The Nationwide Inpatient Pattern database (2012-2014) was queried to determine sufferers who underwent spinal fusion for vertebral column tumors (main benign, main malignant, or metastatic). The speed of BMP-2 use was calculated and affected person/operative elements related to its use had been additionally investigated.
RESULTS: A complete of 9,375 sufferers who underwent fusion surgical procedure for spinal tumors between 2012 and 2014 had been recognized, with 540 instances utilizing BMP-2 (5.eight%). Primarily based on preoperative prognosis, the speed of BMP-2 use in main benign tumor surgical procedure was four.9%, 7.6% for main malignant tumors, and 5.7% for metastatic lesions (p-value zero.607). The general complication price was 13.2% (13.four% within the NO-BMP-2 group vs. 11.1% within the BMP-2 group (p=zero.504). Sufferers who acquired this development issue had been much less prone to have epidural spinal wire compression at presentation (37.zero% vs. 49.2%, p=zero.014), and extra prone to have elective surgical procedure (53.7% vs. 37.7%, p<zero.001). Primarily based on hospital location, the very best utilization of BMP-2 was within the South (7.four% price, p=zero.002). There was no statistical distinction between age, intercourse, insurance coverage standing, co-morbidities, the presence of a pathological fracture, or the usage of inpatient radio/chemotherapy between sufferers who acquired BMP-2 and controls.
CONCLUSION: BMP-2 has been used off-label to advertise arthrodesis; nevertheless, its use on sufferers with spinal tumors is controversial. On this nationwide research, BMP-2 use was highest within the South, in sufferers with out epidural wire compression at presentation, and in elective instances.

PMID: 29733987 [PubMed – as supplied by publisher]

Share to care...

Share on facebook
Facebook
Share on twitter
Twitter
Share on pinterest
Pinterest
Share on google
Google+
Share on linkedin
LinkedIn
Share on skype
Skype

What we do...

The Harley Street Hospital

Testimonials

What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

We treat all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

What our patients say about us ......