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Understanding The Impact Of Early Depressive Burden On Patient Perceptions Of Outcomes Following Cervical Disc Replacement – Cervical Disc Replacement

This article evaluates the impact of early depressive burden on patient-reported outcome measures (PROMs) in the context of cervical disc replacement (CDR). The study analyzed patients who underwent primary elective CDR and had recorded preoperative and 6-week postoperative Patient Health Questionnaire (PHQ-9) scores. The patients were divided into two cohorts based on their PHQ-9 scores, with one group having lower burden and the other having higher burden. The results showed that patients with a higher depressive burden experienced greater improvements in depressive symptoms at both the 6-week and final follow-up assessments. On the other hand, patients with a lower depressive burden had greater improvements in physical function at the final follow-up assessment. The study highlights the importance of considering early depressive burden when evaluating PROMs in patients undergoing CDR. The keywords for this study include CDR, mental health, PHQ-9, and PROMs

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : finest spine hospital on Harley Street UK

Published article

CONCLUSIONS: Patients with a greater depressive burden were more likely to experience greater magnitudes of improvements in PHQ-9 at both 6-week and final follow-up and experience clinically meaningful improvement in depressive symptoms. Patients with a lesser depressive burden were more likely to experience a greater magnitude of improvement in PROMIS-PF at final follow-up and experience clinically meaningful improvement in physical function.

Cervical Disc Replacement Surgery Expert. Best Spinal Surgeon UK
Abstract Objective: To evaluate the effect of early depressive burden on PROMs in the setting of cervical disc replacement (CDR). Methods: Patients who had undergone primary elective CDR with recorded preoperative and 6-week postoperative 9-item Patient Health Questionnaire (PHQ-9) scores were identified. Early depressive burden was calculated via addition of the preoperative and 6-week PHQ-9,

Abstract

Objective: To evaluate the effect of early depressive burden on PROMs in the setting of cervical disc replacement (CDR).

Methods: Patients who had undergone primary elective CDR with recorded preoperative and 6-week postoperative 9-item Patient Health Questionnaire (PHQ-9) scores were identified. Early depressive burden was calculated via addition of the preoperative and 6-week PHQ-9 scores. Patients were divided into 2 cohorts, those with summative PHQ-9 scores beneath one-half standard deviation less than the mean (Lesser Burden; LB) and those with summative PHQ-9 scores above one-half standard deviation greater than the mean (Greater Burden; GB). Magnitude of improvement in PROMs (ΔPROM) was compared within and between cohorts at 6-weeks (ΔPROM-6W) and final follow-up (ΔPROM-FF). PROMs evaluated included PROMIS-PF/NDI/VAS-Neck (VAS-N)/VAS-Arm (VAS-A)/PHQ-9.

Results: Fifty-five patients were included with 34 in the LB cohort. The LB cohort demonstrated improvements from the preoperative baseline in 6-week PROMIS-PF/NDI/VAS-N/VAS-A (P ≤ 0.012, all). The GB cohort demonstrated improvements from the preoperative baseline in 6-week NDI/VAS-N/VAS-A/PHQ-9 (P ≤ 0.038, all). The GB cohort demonstrated greater ΔPROM-6W and ΔPROM-FF in PHQ-9 (P ≤ 0.047, both). The LB cohort demonstrated a greater ΔPROM-FF in PROMIS-PF (P = 0.023).

Conclusions: Patients with a greater depressive burden were more likely to experience greater magnitudes of improvements in PHQ-9 at both 6-week and final follow-up and experience clinically meaningful improvement in depressive symptoms. Patients with a lesser depressive burden were more likely to experience a greater magnitude of improvement in PROMIS-PF at final follow-up and experience clinically meaningful improvement in physical function.

Keywords: CDR; Mental health; PHQ-9; PROMs.

The London Spine Unit : finest spine hospital on Harley Street UK

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Understanding the Impact of Early Depressive Burden on Patient Perceptions of Outcomes Following Cervical Disc Replacement

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Abstract Objective: To evaluate the effect of early depressive burden on PROMs in the setting of cervical disc replacement (CDR). Methods: Patients who had undergone primary elective CDR with recorded preoperative and 6-week postoperative 9-item Patient Health Questionnaire (PHQ-9) scores were identified. Early depressive burden was calculated via addition of the preoperative and 6-week PHQ-9

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