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Two circumstances of major leptomeningeal melanomatosis mimicking subacute meningitis.

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Two circumstances of major leptomeningeal melanomatosis mimicking subacute meningitis.

Neuroradiol J. 2018 Feb;31(1):42-46

Authors: Aslan S, Gocmen R, Acar NP, Khasiyev F, Gumeler E, Soylemezoglu F, Tuncer A, Arsava EM, Topçuoglu MA, Unal Cevik I

Summary
Main involvement of leptomeninges with melanocytic tumours is never seen and its prognosis is difficult. Right here we summarise two circumstances of major leptomeningeal melanomatosis presenting as subacute meningitis. Each circumstances have pleocytosis and excessive protein on cerebrospinal fluid evaluation, and demonstrated atypical cells on cytology. On magnetic resonance imaging, there may be diffuse leptomeningal thickening and avid enhancement of intracranial and intraspinal leptomeninges. One in every of them demonstrates T1 shortening as a result of magnetic results of melanin, the opposite case is amelanotic and exhibits hypointensity on precontrast T1-weighted photos. Each circumstances could be recognized with biopsy. In conclusion, these circumstances spotlight the significance of the right interpretation of cytological and magnetic resonance imaging findings in sufferers with atypical findings.

PMID: 28627959 [PubMed – indexed for MEDLINE]

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