Two instances of main leptomeningeal melanomatosis mimicking subacute meningitis.
Neuroradiol J. 2018 Feb;31(1):42-46
Authors: Aslan S, Gocmen R, Acar NP, Khasiyev F, Gumeler E, Soylemezoglu F, Tuncer A, Arsava EM, Topçuoglu MA, Unal Cevik I
Main involvement of leptomeninges with melanocytic tumours is never seen and its analysis is difficult. Right here we summarise two instances of main leptomeningeal melanomatosis presenting as subacute meningitis. Each instances have pleocytosis and excessive protein on cerebrospinal fluid evaluation, and demonstrated atypical cells on cytology. On magnetic resonance imaging, there’s diffuse leptomeningal thickening and avid enhancement of intracranial and intraspinal leptomeninges. One in every of them demonstrates T1 shortening on account of magnetic results of melanin, the opposite case is amelanotic and reveals hypointensity on precontrast T1-weighted photographs. Each instances will be identified with biopsy. In conclusion, these instances spotlight the significance of the proper interpretation of cytological and magnetic resonance imaging findings in sufferers with atypical findings.
PMID: 28627959 [PubMed – indexed for MEDLINE]