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Transthyretin Amyloid Deposition In Ligamentum Flavum (LF) Is Significantly Correlated With LF And Epidural Fat Hypertrophy In Patients With Lumbar Spinal Stenosis London Spine Lumbar Stenosis

The article discusses lumbar spinal stenosis (LSS), a degenerative disease characterized by symptoms such as intermittent claudication and numbness in the lower extremities. The compression of nerve tissue in the lumbar spinal canal is responsible for these symptoms. The study reveals that surgically harvested ligamentum flavum (LF) from LSS patients exhibited increased thickness when transthyretin (TTR), a protein responsible for amyloidosis, was deposited in the LF. The deposition of TTR in LF was found to be significantly associated with LF hypertrophy and epidural fat thickness. Further experiments revealed that TTR stimulates the differentiation of mesenchymal cells into adipocytes. The findings suggest that targeting TTR could be a potential therapeutic approach to prevent LSS development and progression

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
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Published article

Lumbar spinal stenosis (LSS) is a degenerative disease characterized by intermittent claudication and numbness in the lower extremities. These symptoms are caused by the compression of nerve tissue in the lumbar spinal canal. Ligamentum flavum (LF) hypertrophy and spinal epidural lipomatosis in the spinal canal are known to contribute to stenosis of the spinal canal: however, detailed mechanisms underlying LSS are still not fully understood. Here, we show that surgically harvested LFs from LSS…

Spine Lumbar Spinal Stenosis Expert. Best Spinal Surgeon UK
Abstract Lumbar spinal stenosis (LSS) is a degenerative disease characterized by intermittent claudication and numbness in the lower extremities. These symptoms are caused by the compression of nerve tissue in the lumbar spinal canal. Ligamentum flavum (LF) hypertrophy and spinal epidural lipomatosis in the spinal canal are known to contribute to stenosis of the spinal,

Abstract

Lumbar spinal stenosis (LSS) is a degenerative disease characterized by intermittent claudication and numbness in the lower extremities. These symptoms are caused by the compression of nerve tissue in the lumbar spinal canal. Ligamentum flavum (LF) hypertrophy and spinal epidural lipomatosis in the spinal canal are known to contribute to stenosis of the spinal canal: however, detailed mechanisms underlying LSS are still not fully understood. Here, we show that surgically harvested LFs from LSS patients exhibited significantly increased thickness when transthyretin (TTR), the protein responsible for amyloidosis, was deposited in LFs, compared to those without TTR deposition. Multiple regression analysis, which considered age and BMI, revealed a significant association between LF hypertrophy and TTR deposition in LFs. Moreover, TTR deposition in LF was also significantly correlated with epidural fat (EF) thickness based on multiple regression analyses. Mesenchymal cell differentiation into adipocytes was significantly stimulated by TTR in vitro. These results suggest that TTR deposition in LFs is significantly associated with increased LF hypertrophy and EF thickness, and that TTR promotes adipogenesis of mesenchymal cells. Therapeutic agents to prevent TTR deposition in tissues are currently available or under development, and targeting TTR could be a potential therapeutic approach to inhibit LSS development and progression.

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Transthyretin amyloid deposition in ligamentum flavum (LF) is significantly correlated with LF and epidural fat hypertrophy in patients with lumbar spinal stenosis

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Abstract Lumbar spinal stenosis (LSS) is a degenerative disease characterized by intermittent claudication and numbness in the lower extremities. These symptoms are caused by the compression of nerve tissue in the lumbar spinal canal. Ligamentum flavum (LF) hypertrophy and spinal epidural lipomatosis in the spinal canal are known to contribute to stenosis of the spinal

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