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TRANEXAMIC ACID IN REDUCING INTRAOPERATIVE BLEEDING IN DOGS UNDERGOING THORACOLUMBAR AND LUMBAR HEMILAMINECTOMY AND INTERVERTEBRAL DISC FENESTRATION – Lumbar Spinal Stenosis

The article discusses the effectiveness of tranexamic acid in reducing intraoperative bleeding and improving visualization during hemilaminectomy associated with intervertebral disc fenestration (HF) in dogs with intervertebral disc extrusion (IVDE). Sixteen dogs with IVDE undergoing HF were divided into a group receiving tranexamic acid and a control group receiving saline solution. The study found that the use of tranexamic acid significantly reduced blood loss and improved operative visualization compared to the control group. However, a severe arterial thromboembolic complication was observed in one patient potentially related to tranexamic acid. Overall, the study suggests that intraoperative tranexamic acid can be effective in reducing bleeding and facilitating the surgical procedure for dogs with IVDE

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
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Published article

Hemilaminectomy associated with intervertebral disc fenestration (HF) is the most used spinal decompression surgical technique for the treatment of intervertebral disc extrusion (IVDE). The surgical procedure can be hampered by excessive bleeding from the venous sinuses; however, tranexamic acid intravenously (IV) is a possible adjunct to hemostasis in these patients. This study aimed to verify the effectiveness of tranexamic acid in reducing intraoperative bleeding in dogs with thoracolumbar…

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Top Companion Anim Med. 2023 Oct 4:100820. doi: 10.1016/j.tcam.2023.100820. Online ahead of print.ABSTRACTHemilaminectomy associated with intervertebral disc fenestration (HF) is the most used spinal decompression surgical technique for the treatment of intervertebral disc extrusion (IVDE). The surgical procedure can be hampered by excessive bleeding from the venous sinuses; however, tranexamic acid intravenously (IV) is a,

Top Companion Anim Med. 2023 Oct 4:100820. doi: 10.1016/j.tcam.2023.100820. Online ahead of print.

ABSTRACT

Hemilaminectomy associated with intervertebral disc fenestration (HF) is the most used spinal decompression surgical technique for the treatment of intervertebral disc extrusion (IVDE). The surgical procedure can be hampered by excessive bleeding from the venous sinuses; however, tranexamic acid intravenously (IV) is a possible adjunct to hemostasis in these patients. This study aimed to verify the effectiveness of tranexamic acid in reducing intraoperative bleeding in dogs with thoracolumbar and lumbar IVDE submitted to HF. Sixteen dogs with IVDE undergoing HF were included. These were distributed into a TXA group (tranexamic acid 20 mg/kg IV bolus, followed by 2 mg/kg/h IV continuous infusion) (n=8) and a control group, with saline solution (n=8). Blood loss was measured using the gravimetric method. The difficulty of operative visualization due to bleeding was classified by the surgeon. Median blood loss (%) in patients in the TXA group was lower than those in the control group (2.75 ± 1.23 and 4.99 ± 4.44, respectively) (p=0.028). Intraoperative visualization difficulty due to bleeding occurred in 10 patients in the control group, and in no patients in the TXA group. A severe arterial thromboembolic complication was recorded, potentially due to tranexamic acid. The use of intraoperative tranexamic acid was effective in reducing bleeding and facilitating operative visualization in dogs with IVDE undergoing hemilaminectomy and intervertebral disc fenestration.

PMID:37802243 | DOI:10.1016/j.tcam.2023.100820

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TRANEXAMIC ACID IN REDUCING INTRAOPERATIVE BLEEDING IN DOGS UNDERGOING THORACOLUMBAR AND LUMBAR HEMILAMINECTOMY AND INTERVERTEBRAL DISC FENESTRATION

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Top Companion Anim Med. 2023 Oct 4:100820. doi: 10.1016/j.tcam.2023.100820. Online ahead of print.ABSTRACTHemilaminectomy associated with intervertebral disc fenestration (HF) is the most used spinal decompression surgical technique for the treatment of intervertebral disc extrusion (IVDE). The surgical procedure can be hampered by excessive bleeding from the venous sinuses; however, tranexamic acid intravenously (IV) is a

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