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Whole and Visceral Adiposity Are Related With Prevalent Vertebral Fracture in Girls however Not Males at Age 62 Years: The Newcastle Thousand Households Examine.
J Bone Miner Res. 2017 Might;32(5):1109-1115
Authors: Hind Ok, Pearce M, Birrell F
Summary
Low physique weight is a longtime danger issue for osteoporosis and fracture, however the skeletal dangers of upper adiposity are unclear and seem sex-specific and site-dependent. The intention of this research was to research associations of complete fats mass (TFM), visceral adipose tissue (VAT), and C-reactive protein (CRP) with bone mineral density (BMD) and prevalent vertebral fracture (VF) in women and men aged 62 years. A complete of 352 women and men aged 62.5?±?zero.5 years from the Newcastle Thousand Households Examine cohort acquired dual-energy X-ray absorptiometry (DXA) evaluations of femoral neck and lumbar backbone BMD, of the lateral backbone for vertebral fracture evaluation, and of the entire physique for TFM and VAT (GE Lunar CoreScan, Madison, WI, USA). Plasma CRP, FRAX scores, falls within the final 12 months, and occupation at age 50 years had been additionally included within the evaluation. Vertebral fractures had been much less prevalent in ladies than in males (odds ratio [OR]?=?zero.33, p?<?zero.001) and BMD or FRAX scores didn’t differ between individuals with and with out VF. Girls with VF had been heavier and had greater TFM, VAT, and CRP than ladies with out (p?<?zero.001). In ladies, higher (+1 SD) TFM and VAT elevated the chances of any grade VF (TFM: OR?=?1.06, p?=?zero.001; VAT: OR?=?2.50, p?=?zero.002), and higher VAT mass elevated the chances of prevalent delicate VF (OR?=?2.60, p?=?zero.002). In distinction, there have been no associations in males. In each sexes, after controlling for physique weight, neither VAT nor CRP had been related to BMD. In conclusion, no matter BMD, complete and visceral adiposity had been related to prevalent VF in ladies however not in males. Excessive fats mass, significantly if visceral, must be thought-about when assessing VF danger in ladies. Threat elements for VF in males require additional investigation, significantly given their excessive prevalence. © 2017 American Society for Bone and Mineral Analysis.
PMID: 28261864 [PubMed – indexed for MEDLINE]