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Timing of Percutaneous Balloon Kyphoplasty for Osteoporotic Vertebral Compression Fractures Timing of Percutaneous Balloon Kyphoplasty for Osteoporotic Vertebral Compression Fractures







Timing of Percutaneous Balloon Kyphoplasty for Osteoporotic Vertebral Compression Fractures – PubMed









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Meta-Analysis

. 2023 May;26(3):231-243.

Timing of Percutaneous Balloon Kyphoplasty for Osteoporotic Vertebral Compression Fractures

Affiliations


  • PMID:

    37192225

Free article

Meta-Analysis

Timing of Percutaneous Balloon Kyphoplasty for Osteoporotic Vertebral Compression Fractures

Donghua Liu et al.


Pain Physician.


2023 May.

Free article


Abstract


Background:

Percutaneous balloon kyphoplasty (PKP) is widely used to treat osteoporotic vertebral compression fractures (OVCFs). In addition to rapid and effective pain relief, the ability to recover the lost height of fractured vertebral bodies and reduce the risk for complications are believed to be the main advantages of this procedure. However, there is no consensus on the appropriate surgical timing for PKP.


Objectives:

This study systematically evaluated the relationship between the surgical timing of PKP and clinical outcomes to provide more evidence for clinicians to choose the intervention timing.


Study design:

Systematic review and meta-analysis.


Methods:

The PubMed, Embase, Cochrane Library, and Web of Science databases were systematically searched for relevant randomized controlled trials and prospective, and retrospective cohort trials published up to November 13, 2022. All included studies explored the influence of PKP intervention timing for OVCFs. Data regarding clinical and radiographic outcomes and complications were extracted and analyzed.


Results:

Thirteen studies involving 930 patients with symptomatic OVCFs were included. Most patients with symptomatic OVCFs achieved rapid and effective pain relief after PKP. In comparison to delayed PKP intervention, early PKP intervention was associated with similar or better outcomes in terms of pain relief, improvement of function, restoration of vertebral height, and correction of kyphosis deformity. The meta-analysis results showed there was no significant difference in cement leakage rate between early PKP and late PKP (odds ratio [OR] = 1.60, 95% CI, 0.97-2.64, P = 0.07), whereas delayed PKP had a higher risk for adjacent vertebral fractures (AVFs) than early PKP (OR = 0.31, 95% CI: 0.13-0.76, P = 0.01).


Limitations:

The number of included studies was small, and the overall quality of the evidence was very low.


Conclusions:

PKP is an effective treatment for symptomatic OVCFs. Early PKP may achieve similar or better clinical and radiographic outcomes for treating OVCFs than delayed PKP. Furthermore, early PKP intervention had a lower incidence of AVFs and a similar rate of cement leakage compared with delayed PKP. Based on current evidence, early PKP intervention might be more beneficial to patients.


Keywords:

operative timing; osteoporosis; osteoporotic vertebral compression fractures; surgery; Percutaneous balloon kyphoplasty.

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Timing of Percutaneous Balloon Kyphoplasty for Osteoporotic Vertebral Compression Fractures

Timing of Percutaneous Balloon Kyphoplasty for Osteoporotic Vertebral Compression Fractures

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content An official website of the United States government Here’s how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. The

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