Therapeutic Impact of Medical Ozone on Lumbar Disc Herniation.
Med Sci Monit. 2018 Apr 03;24:1962-1969
Authors: Niu T, Lv C, Yi G, Tang H, Gong C, Niu S
BACKGROUND This examine aimed to research the therapeutic impact of low, medium, and excessive concentrations of medical ozone on trauma-induced lumbar disc herniation. MATERIAL AND METHODS A complete of 80 sufferers have been included and have been grouped right into a management group, a low medical ozone (20 ?g/ml) group, a medium medical ozone (40 ?g/ml) group, and a excessive medical ozone (60 ?g/ml) group. The CT scan and enzyme-linked immunosorbent assay (ELISA) have been used to detect IL-6 degree, SOD exercise, IgM, and IgG ranges upon admission and at 6 and 12 months after follow-up. The realm beneath the ROC curve (AUC) was calculated for visible analogue scale (VAS) and effectivity price. RESULTS All sufferers confirmed disc retraction at 6- and 12-month follow-up; whereas sufferers within the medium medical ozone (40 ?g/ml) group confirmed the best disc retraction price. The IL-6, IgM, IgG, and VAS ranges considerably decreased whereas SOD exercise elevated amongst all teams over time (p<zero.05). The AUCIL-6, AUCIgG, AUCIgM, and AUCSOD was closest to 1 within the medium medical ozone (40 ?g/ml) group in contrast with different teams (p<zero.01), with the very best efficacy at 6 (35%) and 12 (85%) months throughout follow-up. CONCLUSIONS Low concentrations of medical ozone (20 ?g/ml and 40 ?g/ml) diminished the serum IL-6, IgG, and IgM expression, presenting as analgesic and anti inflammatory results, whereas excessive concentrations of medical ozone (60 ?g/ml) elevated the serum IL-6, IgG, IgM expression, presenting as ache and pro-inflammatory results. The medical ozone focus of 40 ?g/ml confirmed the optimum remedy efficacy.
PMID: 29611536 [PubMed – in process]