The transpedicular surgical method for the event of intervertebral disc concentrating on regenerative methods in an ovine mannequin.
Eur Backbone J. 2017 Aug;26(eight):2072-2083
Authors: Le Fournier L, Fusellier M, Halgand B, Lesoeur J, Gauthier O, Menei P, Montero-Menei C, Guicheux J, Clouet J
PURPOSE: To analyze the suitability of the transpedicular method (TPA) in a sheep mannequin of IVD regenerative methods METHODS: 24 IVD from 4 sheep had been used. TPA and biopsies of the Nucleus pulposus (NP) had been carried out in 18 IVD (6 IVD management). Seven discographies had been carried out to evaluate the feasibility of injecting distinction agent. MRI, micro-CT scan, and histological analyses had been carried out and the accuracy of the TPA was evaluated. The consequences on the vertebra and endplates had been analyzed.
RESULTS: 83% of our biopsies or injections had been situated within the NP. Osseous fragments in IVD had been noticed in 50%. We noticed two circumstances (11%) of rostral endplate fracture and 5 circumstances (27%) of breaching of the cortical pedicle and encroachment into the spinal canal. Two circumstances of perivertebral venous embolism and two of backflow by means of the canal of the TPA contained in the vertebra had been famous. Vital injury occurred to the bone construction of the vertebra and to the rostral endplate on which the IVD had been inserted.
CONCLUSIONS: TPA induces injury to the endplates, and it might result in neurological impairment and leakage of injected supplies into the systemic circulation. These opposed results should be totally thought-about earlier than continuing with TPA for IVD regenerative methods.
PMID: 28674787 [PubMed – indexed for MEDLINE]