The transpedicular surgical method for the event of intervertebral disc focusing on regenerative methods in an ovine mannequin.
Eur Backbone J. 2017 Aug;26(eight):2072-2083
Authors: Le Fournier L, Fusellier M, Halgand B, Lesoeur J, Gauthier O, Menei P, Montero-Menei C, Guicheux J, Clouet J
PURPOSE: To analyze the suitability of the transpedicular method (TPA) in a sheep mannequin of IVD regenerative methods METHODS: 24 IVD from 4 sheep have been used. TPA and biopsies of the Nucleus pulposus (NP) have been carried out in 18 IVD (6 IVD management). Seven discographies have been carried out to evaluate the feasibility of injecting distinction agent. MRI, micro-CT scan, and histological analyses have been carried out and the accuracy of the TPA was evaluated. The results on the vertebra and endplates have been analyzed.
RESULTS: 83% of our biopsies or injections have been positioned within the NP. Osseous fragments in IVD have been noticed in 50%. We noticed two circumstances (11%) of rostral endplate fracture and 5 circumstances (27%) of breaching of the cortical pedicle and encroachment into the spinal canal. Two circumstances of perivertebral venous embolism and two of backflow by way of the canal of the TPA contained in the vertebra have been famous. Vital harm occurred to the bone construction of the vertebra and to the rostral endplate on which the IVD had been inserted.
CONCLUSIONS: TPA induces harm to the endplates, and it could result in neurological impairment and leakage of injected supplies into the systemic circulation. These hostile results should be totally thought-about earlier than continuing with TPA for IVD regenerative methods.
PMID: 28674787 [PubMed – indexed for MEDLINE]