The protecting results of sumatriptan on vincristine – induced peripheral neuropathy in a rat mannequin.
Neurotoxicology. 2018 Jun 26;67:279-286
Authors: Khalilzadeh M, Panahi G, Rashidian A, Hadian MR, Abdollahi A, Afshari Okay, Shakiba S, Norouzi-Javidan A, Rahimi N, Momeny M, Dehpour AR
Scientific use of vincristine (VCR), an efficient chemotherapeutic agent, has been restricted attributable to its peripheral neuropathy toxicity. Sumatriptan, which is an anti-migraine agent is a particular agonist for 5-hydroxytryptamine 1B, 1D (5HT1B, 1D) receptors. A number of research have proven that sumatriptan exerts anti-inflammatory and immunomodulatory properties. This research aimed to analyze the consequences of sumatriptan on VCR-induced peripheral neuropathy in a rat mannequin. Male Wistar rats have been intraperitoneally injected with VCR and regular saline 4 occasions per week for two weeks. Within the remedy group, sumatriptan (1?mg/kg) was administered intraperitoneally 30?min previous to VCR injection each day. Mortality fee, weight variations and histopathological adjustments have been monitored. Scorching plate, tail flick and motor nerve conduction velocity (MNCV) assessments have been used to guage sensory and motor neuropathy. Ranges of tumor necrosis factor-alpha (TNF-?), interleukin-1? (IL-1?) and caspase-Three within the dorsal ganglion root have been assessed by quantitative reverse transcription-PCR (qRT-PCR). Furthermore, the protein ranges of p65 nuclear issue kappa B (NF-<kappa?>?B) and phospho-p65 NF-<kappa?>?B have been examined by Western blot evaluation. Co-administration of sumatriptan with VCR considerably reversed alterations within the sizzling plate, tail flick threshold and sciatic MNCV induced by VCR and likewise prevented blended sensory-motor neuropathy, as indicated by higher common circumstances, behavioral and electrophysiological outcomes. As well as, sumatriptan improved the physique weight reduction attributable to VCR. The mRNA ranges of TNF-?, IL-1? and caspase-Three have been considerably diminished within the remedy group. These findings have been confirmed by histopathological evaluation. In conclusion, this research demonstrated that sumatriptan considerably attenuated VCR-induced neuropathy and might be thought of as a neuroprotective agent to forestall the VCR-induced neuropathy.
PMID: 29958920 [PubMed – as supplied by publisher]