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The pathologic mechanisms underlying lumbar distraction spinal wire damage in rabbits.

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The pathologic mechanisms underlying lumbar distraction spinal wire damage in rabbits.

Backbone J. 2017 Nov;17(11):1665-1673

Authors: Wu D, Zheng C, Wu J, Xue J, Huang R, Wu D, Music Y

BACKGROUND CONTEXT: A dependable experimental rabbit mannequin of distraction spinal wire damage (SCI) was established to efficiently simulate gradable and replicable distraction SCI. Nonetheless, additional analysis is required to elucidate the pathologic mechanisms underlying distraction SCI.
PURPOSE: The purpose of this examine was to analyze the pathologic mechanisms underlying lumbar distraction SCI in rabbits.
STUDY DESIGN: That is an animal laboratory examine.
METHODS: Utilizing a self-designed backbone distractor, the experimental animals have been divided right into a management group and 10%, 20%, and 30% distraction teams. Pathologic adjustments to the spinal wire microvessels within the early stage of distraction SCI have been recognized by perfusion of the spinal wire vasculature with ink, manufacturing of clear specimens, remark by gentle microscopy, and remark of corrosion casts of the spinal wire microvascular structure by scanning electron microscopy. Malondialdehyde (MDA) and superoxide dismutase (SOD) concentrations within the injured spinal wire tissue have been measured after eight hours.
RESULTS: With an rising diploma and period of distraction, the spinal wire microvessels have been solely partially stuffed and had the looks of spasm till rupture and hemorrhage have been noticed. The MDA focus elevated and the SOD focus decreased within the spinal wire tissue.
CONCLUSIONS: Adjustments to the interior and exterior spinal wire vessels led to spinal wire ischemia, which is a main pathologic mechanism of distraction SCI. Lipid peroxidation mediated by free radicals took half in secondary pathologic harm of distraction SCI.

PMID: 28662993 [PubMed – indexed for MEDLINE]

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