The P2X7 receptor in dorsal root ganglia is concerned in HIV gp120-associated neuropathic ache.
Mind Res Bull. 2017 Oct;135:25-32
Authors: Wu B, Peng L, Xie J, Zou L, Zhu Q, Jiang H, Yi Z, Wang S, Xue Y, Gao Y, Li G, Liu S, Zhang C, Li G, Liang S, Xiong H
Human immunodeficiency virus (HIV)-associated neuropathic ache is widespread, and research have proven that HIV envelope glycoprotein 120 (gp120) can immediately stimulate main sensory afferent neurons inflicting hyperalgesia. The P2X7 receptor within the dorsal root ganglia (DRG) is concerned in ache transmission and is intently associated to the inflammatory and immune response. On this examine, we aimed to discover the function of the P2X7 receptor in gp120-induced neuropathic ache utilizing a rat mannequin particular for this kind of ache. The outcomes confirmed that mechanical hyperalgesia, thermal hyperalgesia and P2X7 expression ranges have been elevated in rats handled with gp120. The P2X7 antagonist, good blue G (BBG), decreased hyperalgesia and P2X7 expression ranges in rats handled with gp120. BBG additionally decreased IL-1? and TNF-? receptor expression and ERK1/2 phosphorylation ranges and elevated IL-10 expression within the gp120-treated rat DRG. As well as, P2X7 agonist (BzATP)-activated currents in DRG neurons cultured with gp120 have been bigger than these in management neurons, and the inhibitory impact of BBG on BzATP-induced currents in gp120-treated DRG neurons was bigger than that in management neurons. Subsequently, inhibition of the P2X7 receptor in rat DRG relieved gp120-induced mechanical hyperalgesia and thermal hyperalgesia.
PMID: 28919433 [PubMed – indexed for MEDLINE]