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The neuroprotective effects of Reg-2 following spinal cord transection injury

This study was designed to elucidate the potential neuroprotective effects of Reg-2 (regeneration gene protein 2) in a rodent model of spinal cord transection injury at the ninth thoracic level. Reg-2 at 100 and 500 mug, recombinant rat ciliary neurotrophic factor, or vehicle were delivered intrathecally using Alzet miniosmotic pumps. We found that Reg-2 treatment significantly reduced neuronal death in the spinal cord. There was also an attenuation of inflammation at the injury site and an increase in white matter sparing and retained myelination. Retrograde tracing revealed that Reg-2 protected axons of long descending pathways at 6 weeks post-SCI, and the number of FluoroGold-labeled neurons in spinal and supraspinal regions was also significantly increased. Immunofluorescent staining confirmed that the spared white matter contained neurofilament-positive axons. Moreover, behavioral improvements were revealed by Basso Beattie Bresnahan locomotor rating scores and grid-walk analysis. These results suggest that Reg-2 might promote functional recovery by increasing axonal growth, inhibiting neuronal apoptosis, and attenuating spinal cord secondary injury after SCI

Keywords : administration & dosage,analysis,Animals,Antigens,Antigens,Neoplasm,Apoptosis,Apoptosis Regulatory Proteins,Axons,Biomarkers,Biomarkers,Tumor,Cell Death,Cervical Vertebrae,China,Ciliary Neurotrophic Factor,Disease Models,Animal,Female,Growth,Inflammation,Injections,Spinal,injuries,Lectins,Lectins,C-Type,metabolism,Nerve Regeneration,Neural Inhibition,Neurons,Neuroprotective Agents,Pancreatitis-Associated Proteins,physiology,physiopathology,Random Allocation,Rats,Rats,Sprague-Dawley,Recovery of Function,Regeneration,secondary,Spinal Cord,Spinal Cord Injuries,therapeutic use,therapy,Thoracic Vertebrae,Universities,, Neuroprotective,Effects,Reg2,Following, lower back pain x ray or mri

Date of Publication : 2011 Jan

Authors : Fang M;Wang J;Huang JY;Ling SC;Rudd JA;Hu ZY;Yew DT;Han S;

Organisation : Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, People’s Republic of China

Journal of Publication : Anat Rec (Hoboken )

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21157914

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