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[The liquid biopsies: What is their contribution to the management of cancer?]

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[The liquid biopsies: What is their contribution to the management of cancer?]

Rev Med Interne. 2018 Jun 13;:

Authors: Wechsler J

Summary
The « liquid biopsies » are samples of liquids akin to blood, urine, spinal fluid that may include tumor materials. Medical assays have been primarily centered on the peripheral blood containing circulating tumor cells and circulating tumor DNA. The circulating tumor cells are most cancers cells launched from the first tumor or recurrences or metastases. They enter into the bloodstream after passing by way of the vessel wall. It’s attainable to investigate the circulating tumor cells by the use of all cytologic and biomolecular methods. The free circulating tumor DNA is made from fragments of DNA launched by dwelling or necrotic tumor cells proceeded from anyplace of the organism. The free circulating tumor DNA and DNA from circulating tumor cells present structural rearrangements amongst which some are therapeutic targets. Many research confirmed that circulating tumor cells and circulating tumor DNA analyses are helpful in revealing recurrences and monitoring therapeutic targets.

PMID: 29909000 [PubMed – as supplied by publisher]

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