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The impact of demineralized bone matrix characteristics on pseudarthrosis and surgical outcomes after posterolateral lumbar decompression and fusion – Published Article

This article examines the fusion rates and surgical outcomes of lumbar fusion surgery, specifically focusing on the type of demineralized bone matrix (DBM) carrier allograft, the presence or absence of a carrier, and the presence of bone fibers in DBM. The study included patients who underwent single-level posterolateral decompression and fusion between L3 and L5. Fusion status was assessed based on radiographic evaluation, and the data was analyzed to determine the impact of carrier type and bone fibers on readmission rates and the likelihood of successful fusion. The results showed no significant differences in fusion rates or surgical outcomes between DBM carriers containing glycerol, sodium hyaluronate, or no carrier. Additionally, the presence of bone fibers did not have a significant impact on fusion likelihood

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : most experienced day surgery unit on Harley Street UK

Published article

CONCLUSION: Our study found no significant differences between DBM containing glycerol, sodium hyaluronate, or no carrier regarding fusion rates or surgical outcomes after single-level PLDF. Bone particulates versus bone fibers also had no significant differences regarding the likelihood of bony fusion.

Lumbar Decompression Surgery Expert. Best Spinal Surgeon UK
J Craniovertebr Junction Spine. 2023 Apr-Jun;14(2):194-200. doi: 10.4103/jcvjs.jcvjs_45_23. Epub 2023 Jun 13.ABSTRACTOBJECTIVES: The objectives of our study were to compare the fusion rates and surgical outcomes of lumbar fusion surgery based on the (1) type of demineralized bone matrix (DBM) carrier allograft, (2) the presence/absence of a carrier, and (3) the presence of bone fibers,

J Craniovertebr Junction Spine. 2023 Apr-Jun;14(2):194-200. doi: 10.4103/jcvjs.jcvjs_45_23. Epub 2023 Jun 13.

ABSTRACT

OBJECTIVES: The objectives of our study were to compare the fusion rates and surgical outcomes of lumbar fusion surgery based on the (1) type of demineralized bone matrix (DBM) carrier allograft, (2) the presence/absence of a carrier, and (3) the presence of bone fibers in DBM.

METHODS: Patients >18 years of age who underwent single-level posterolateral decompression and fusion (PLDF) between L3 and L5 between 2014 and 2021 were retrospectively identified. We assessed bone grafts based on carrier type (no carrier, sodium hyaluronate carrier, and glycerol carrier) and the presence of bone fibers. Fusion status was determined based on a radiographic assessment of bony bridging, screw loosening, or change in segmental lordosis >5°. Analyses were performed to assess fusion rates and surgical outcomes.

RESULTS: Fifty-four patients were given DBM with a hyaluronate carrier, 75 had a glycerol carrier, and 94 patients were given DBM without a carrier. DBM carrier type, bone fibers, and carrier presence had no impact on 90-day readmission rates (P = 0.195, P = 0.099, and P = 1.000, respectively) or surgical readmissions (P = 0.562, P = 0.248, and P = 0.640, respectively). Multivariable logistic regression analysis found that type of carrier, presence of fibers (odds ratio [OR] = 1.106 [0.524-2.456], P = 0.797), and presence of a carrier (OR = 0.701 [0.370-1.327], P = 0.274) were also not significantly associated with successful fusion likelihood.

CONCLUSION: Our study found no significant differences between DBM containing glycerol, sodium hyaluronate, or no carrier regarding fusion rates or surgical outcomes after single-level PLDF. Bone particulates versus bone fibers also had no significant differences regarding the likelihood of bony fusion.

PMID:37448499 | PMC:PMC10336891 | DOI:10.4103/jcvjs.jcvjs_45_23

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The impact of demineralized bone matrix characteristics on pseudarthrosis and surgical outcomes after posterolateral lumbar decompression and fusion

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J Craniovertebr Junction Spine. 2023 Apr-Jun;14(2):194-200. doi: 10.4103/jcvjs.jcvjs_45_23. Epub 2023 Jun 13.ABSTRACTOBJECTIVES: The objectives of our study were to compare the fusion rates and surgical outcomes of lumbar fusion surgery based on the (1) type of demineralized bone matrix (DBM) carrier allograft, (2) the presence/absence of a carrier, and (3) the presence of bone fibers

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