Menu
Menu
19 Harley St, London, W1G 9QJ, UK
We are London's Top Spine Clinic

The impact of collagen sponge composite bone marrow mesenchymal stem cells (BMSCs) in inducing interbody fusion.

[ad_1]

Related Articles

The impact of collagen sponge composite bone marrow mesenchymal stem cells (BMSCs) in inducing interbody fusion.

Eur Rev Med Pharmacol Sci. 2018 Sep;22(18):5822-5827

Authors: Zheng WD, Ming JJ, Chang WL

Abstract
OBJECTIVE: To assess the effectiveness of bone mesenchymal stem cells (BMSCs) in the induction of interbody fusion.
PATIENTS AND METHODS: The 3rd generation BMSCs were seeded on collagen sponge scaffold and cultured in osteoblast induction medium for 3 weeks to prepare cell-scaffold complex. Thirty patients were randomly divided into three groups to establish the L4/L5 interbody fusion model. The cell-scaffold complex was implanted in the intervertebral space in group I, the collagen sponge scaffold was implanted in group II, and the autologous iliac crest spongy bone was implanted in group III. Palpation, radiography, micro-CT, and histology were performed on the 12th weeks after operation to evaluate osteogenesis and spinal fusion.
RESULTS: BMSCs differentiated into osteoblasts in the cell-scaffold complex after osteogenic induction for 3 weeks. The spinal fusion rates in group I, II, and III were 40%, 0%, and 70%, respectively. Micro-CT and histological examination showed mature bone marrow and trabecular bone formation in the fusion segments. The new bone was integrated with the upper and lower vertebral body. The bone trabecula in group III was stronger than group I. The surgical segments in group II was scar tissue without collagen sponge residue.
CONCLUSIONS: BMSCs can induce osseous fusion in the lumbar vertebra.

PMID: 30280761 [PubMed – in process]

[ad_2]

Share to care...

Share on facebook
Facebook
Share on twitter
Twitter
Share on pinterest
Pinterest
Share on google
Google+
Share on linkedin
LinkedIn
Share on skype
Skype

What we do...

The Harley Street Hospital

Testimonials

What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

We treat all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

What our patients say about us ......

Paraspinal atrophy

I was very impressed with the consultation and diagnosis I received at the Hospital. The treatment (injection into the spine) did help but not as

Read More »