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The impact of glutamine and arginine-enriched dietary help on high quality of life in head and neck most cancers sufferers handled with IMRT.

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The impact of glutamine and arginine-enriched dietary help on high quality of life in head and neck most cancers sufferers handled with IMRT.

Clin Nutr ESPEN. 2016 Dec;16:30-35

Authors: Yuce Sari S, Yazici G, Yuce D, Karabulut E, Cengiz M, Ozyigit G

Summary
BACKGROUND AND AIMS: Oral mucositis and esophagitis are frequent acute toxicities of radiotherapy (RT) for head and neck most cancers (HNC). With the intention to lower the charges of those toxicities, we in contrast high quality of life in HNC sufferers that did and didn’t obtain a glutamine and arginine-enriched resolution (GAES) throughout RT.
METHODS: A complete of 29 sufferers obtained intensity-modulated radiotherapy (IMRT); 15 used GAES b.i.d. in the course of the therapy, and a matched cohort of 14 sufferers didn’t. Sufferers have been administered the EORTC QLQ-C30, QLQ-H&N35 and QLQ-OES18 questionnaires on the first, 15th, and final days of IMRT.
RESULTS: The worldwide well being standing, purposeful and symptom scale scores have been comparable in each teams on the first day of IMRT. On the 15th and final days, the scores of social features (p = zero.01 and p = zero.012), ache (p = zero.002 and p = zero.002), urge for food (p = zero.01 and p = zero.02), dry mouth (p = zero.001 and p = zero.03), sticky saliva (p = zero.zero03 and p = zero.04), hassle with style (p = zero.001 and p = zero.03), hassle with social consuming (p = zero.zero04 and p = zero.006), and swallowing issues (p = zero.002 and p = zero.046) have been considerably worse within the management group.
CONCLUSIONS: High quality of life is negatively affected by IMRT; nonetheless, use of GAES could mediate this adverse impact.

PMID: 28531452 [PubMed – indexed for MEDLINE]

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