19 Harley St, London, W1G 9QJ, UK

The basis for diminished functional recovery after delayed peripheral nerve repair

The postsurgical period during which neurons remain without target connections (chronic axotomy) and distal nerve stumps and target muscles are denervated (chronic denervation) deleteriously affects functional recovery. An autologous nerve graft and cross-suture paradigm in Sprague Dawley rats was used to systematically and independently control time of motoneuron axotomy, denervation of distal nerve sheaths, and muscle denervation to determine relative contributions of each factor to recovery failure. Tibial (TIB) nerve was cross-sutured to common peroneal (CP) nerve via a contralateral 15 mm nerve autograft to reinnervate the tibialis anterior (TA) muscle immediately or after prolonging TIB axotomy, CP autograft denervation, or TA muscle denervation. Numbers of motoneurons that reinnervated TA muscle declined exponentially from 99 +/- 15 to asymptotic mean (+/- SE) values of 35 +/- 1, 41 +/- 10, and 13 +/- 5, respectively. Enlarged reinnervated motor units fully compensated for reduced motoneuron numbers after prolonged axotomy and autograft denervation, but the maximal threefold enlargement did not compensate for the severe loss of regenerating nerves through chronically denervated nerve stumps and for failure of reinnervated muscle fibers to recover from denervation atrophy. Muscle force, weight, and cross-sectional area declined. Our results demonstrate that chronic denervation of the distal stump plays a key role in reduced nerve regeneration, but the denervated muscle is also a contributing factor. That chronic Schwann cell denervation within the nerve autograft reduced regeneration less than after the denervation of both CP nerve stump and TA muscle, argues that chronic muscle denervation negatively impacts nerve regeneration

Keywords : Adenosine,Adenosine Triphosphatases,administration & dosage,Analysis of Variance,Animals,Atrophy,Axotomy,Disease Models,Animal,Electromyography,enzymology,Female,Glucose,Isometric Contraction,Laminectomy,metabolism,methods,Motor Neurons,Muscle Denervation,Muscle Fibers,Fast-Twitch,Muscle Fibers,Skeletal,Muscle,Skeletal,Nerve Regeneration,Neurons,pathology,physiology,physiopathology,Rats,Rats,Sprague-Dawley,Recovery of Function,Regeneration,Sciatic Neuropathy,Spinal Cord Injuries,surgery,Time,Time Factors,Transplantation,Autologous,Universities,, Basis,Diminished,Functional,Recovery, trigger point electrical stimulation

Date of Publication : 2011 Apr 6

Authors : Gordon T;Tyreman N;Raji MA;

Organisation : Centre for Neuroscience, Department of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2S2, Canada. tessat.gordon@gmail.com

Journal of Publication : J Neurosci

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21471367

The London Spine Unit : Harley Street UK. Specialists in Cutting Edge Technologies for Spinal Surgery

Make an Appointment 

Trustpilot Reviews
Doctify Reviews
Top Doctor Reviews

Skeletal-related events due to bone metastases from differentiated thyroid cancer | Therapeutic massage for back pain

What our patients say ...

Consultant Spine Surgeon
Consultant Spine Surgeon
Consultant Spine Surgeon

This surgical technique consists of a percutaneous approach for the treatment of small to medium size hernias of the intervertebral disc by laser energy. The main objective is to reduce the intradiscal pressure in the nucleus pulposus

Laser Disc Surgery can be performed under local anaesthetic as a day case at our centre on the prestigious Harley Street.
What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

treatment of all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

If you have any emergency Doctor’s need, simply call our 24 hour emergency

Your personal case manager will ensure that you receive the best possible care.

Call Now 

+44 844 589 2020
+44 203 973 8810