The role of TGF-beta1/Smad2/3 pathway in platelet-rich plasma in retarding intervertebral disc degeneration

By London Spine

Recent studies have suggested that platelet-rich plasma (PRP) injections are an effective way to retard intervertebral disc degeneration, but the mechanism of action is unclear. Activated platelets release some growth factors, such as transforming growth factor-beta1 (TGF-beta1), which positively modulate the extracellular matrix of nucleus pulposus cells. The purpose of this study was to explore…