Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study.

By London Spine

Related Articles Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study. Eur Spine J. 2019 Mar 07;: Authors: Yurube T, Buchser WJ, Moon HJ, Hartman RA, Takayama K, Kawakami Y, Nishida K, Kurosaka M, Vo NV, Kang JD, Lotze MT, Sowa GA Abstract PURPOSE: The loss…

Prospective study on serum metal levels in patients with metal-on-metal lumbar disc arthroplasty.

By London Spine
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Prospective study on serum metal levels in patients with metal-on-metal lumbar disc arthroplasty.

Eur Spine J. 2012 Nov 20;

Authors: Gornet MF, Burkus JK, Harper ML, Chan FW, Skipor AK, Jacobs JJ

Abstract
PURPOSE: Metal-on-metal total disc replacement is a recent alternative treatment for degenerative disc disease. Wear and corrosion of these implants can lead to local and systemic transport of metal debris. This prospective longitudinal study examined the serum chromium and cobalt levels in 24 patients with cobalt-chromium alloy metal-on-metal lumbar disc replacements. METHODS: Serum was assayed for chromium (Cr) and cobalt (Co) using high-resolution inductively-coupled plasma-mass spectrometry. Detection limits were 0.015 ng/mL for Cr and 0.04 ng/mL for Co. RESULTS: Median serum Co levels at pre-op, 3, 6, 12, 24, and 36-months post-op were 0.10, 1.03, 0.96, 0.98, 0.67, and 0.52 ng/mL, respectively. Median serum Cr levels were 0.06, 0.49, 0.65, 0.43, 0.52, and 0.50 ng/mL, respectively. CONCLUSION: In general, these results indicated that serum Co and Cr levels are elevated at all postoperative time points and are of the same order of magnitude as those observed in well-functioning metal-on-metal surface replacements of the hip and in metal-on-metal total hip replacements at similar postoperative time points.

PMID: 23179981 [PubMed – as supplied by publisher]