Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis.

By London Spine

Related Articles Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis. Cell Physiol Biochem. 2018;48(3):880-890 Authors: Zhou T, Chen C, Xu C, Zhou H, Gao B, Su D, Liao Z, Li Y, Yang S, Su P Abstract BACKGROUND/AIMS: Three rare MAPK7 variants that predispose individuals to adolescent idiopathic scoliosis have previously been identified. However, the…

Proximal junctional vertebral fracture-subluxation after adult spine deformity surgery. Does vertebral augmentation avoid this complication? A case report.

By London Spine
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Proximal junctional vertebral fracture-subluxation after adult spine deformity surgery. Does vertebral augmentation avoid this complication? A case report.

Scoliosis. 2012;7(1):16

Authors: Fernández-Baíllo N, Sánchez Márquez JM, Sánchez Pérez-Grueso FJ, García Fernández A

Abstract
BACKGROUND: To report to the orthopedic community a case of vertebral fracture and adjacent vertebral subluxation through the upper instrumented vertebra after thoracolumbar fusion with augmentation of the cranial level.
METHODS: This report reviewed the patient`s medical record, her imaging studies and related literature. The possible factors contributing to this fracture are hypothesized.
RESULTS: A 70-year-old woman underwent decompressive surgery and posterolateral fusion for adult lumbar scoliosis. We used pedicular screws from T10 to S1 and iliac screw at the right side, augmented with cement at T10, T11, L1, L5 and S1; and prophylactic vertebroplasty at T9 to avoid the “topping-off syndrome”.Thirty days after discharge, without recognizable inciting trauma, the patient complained of pain in the lower thoracic area. The exam revealed overall neurological deficit below the level of fracture.CT scan and MRI demonstrated a T10 vertebral collapse and T9 vertebral subluxation with morphologic features of flexion-distraction fracture through the upper edge of the screw.At this point, the authors performed posterior decompression at T9 to T10 and extended posterolateral arthrodesis from T2 to T10.To our knowledge, this is an unreported fracture.
CONCLUSIONS: Augmentation of the cranial level in a long thoracolumbar fusion has been developed to avoid the junctional kyphosis and compression fractures at that level. We alert the orthopedic community that this augmentation may lead to further and more severe fractures, although this opinion requires investigation for confirmation.

PMID: 22947422 [PubMed]

Spontaneous resolution of scoliosis associated with lumbar spondylolisthesis: a case report.

By London Spine
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Spontaneous resolution of scoliosis associated with lumbar spondylolisthesis: a case report.

Spine J. 2013 Feb 12;

Authors: Zhou Z, Song Y, Cai Q, Kong Q

Abstract
BACKGROUND CONTEXT: Scoliosis in association with spondylolisthesis is a common phenomenon. According to the traditional opinion, scoliosis should be managed depending on its classification and flexibility. Recently, Crostelli and Mazza proposed a new opinion toward this topic. They advocate that spondylolisthesis-associated scoliosis, especially severe scoliosis, should be considered as idiopathic scoliosis and must be treated with the same principles used in the treatment of idiopathic scoliosis. According to their viewpoints, more scoliotic curves in association with spondylolisthesis need to be treated, either surgically or conservatively. PURPOSE: To describe the spontaneous correction of a severe case of scoliosis by internal fixation of the spondylolisthesis. STUDY DESIGN: Case report of a patient with scoliosis developing in association with high-grade lumbar spondylolisthesis. METHODS: A 12-year-old girl presented with a 2-year history of spinal curvature. She did not have low back or leg pain. The scoliotic deformity corrected readily in the supine position. Radiographs revealed 88% slippage of L5 on S1 in addition to a long section curve of the spine with the main 50° curve at the thoracic level. The spondylolisthesis was repaired with segmental instrumentation and circumferential fusion of L5 and S1. RESULTS: The scoliosis showed spontaneous resolution gradually after lumbosacral fusion and reached a complete correction 2 years after surgery. CONCLUSIONS: The relationship between scoliosis and spondylolisthesis is complex. If scoliosis is considered to be caused by spondylolisthesis, surgery for the latter condition might be the only required intervention for the patient. Unnecessary operation for scoliosis should be avoided.

PMID: 23415020 [PubMed – as supplied by publisher]