Endogenous TGF-? Activity Limits TSLP Expression in the Intervertebral Disc Tissue by Suppressing NF-?B Activation.

By London Spine
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Endogenous TGF-β Activity Limits TSLP Expression in the Intervertebral Disc Tissue by Suppressing NF-κB Activation.

J Orthop Res. 2013 Mar 11;

Authors: Zhu Y, Ohba T, Ando T, Fujita K, Koyama K, Nakamura Y, Katoh R, Haro H, Nakao A

Abstract
Thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine, is highly expressed in herniated disc (HD) tissue and may act as a key molecule for the initiation of macrophage recruitment into the tissue and natural resorption of HD. However, it remains unclear how TSLP expression is regulated in the intervertebral discs. This study showed that expression of TSLP and phosphorylated NF-κB in HD tissue samples was inversely correlated with expression of phosphorylated Smad2/3 (an indicator of active TGF-β signaling) and vice versa in posterior lumbar spinal fusion samples. The pharmacological blockades of endogenous TGF-β activity induced TSLP expression in mouse intervertebral disc tissue culture, which was inhibited by NF-κB inhibitors. Additionally, phosphorylation of Smad2/3 was constitutively detected in mouse intervertebral disc tissue in the steady states. Collectively, these results suggest that endogenous TGF-β activity limits TSLP expression in intervertebral disc tissue in the steady states by suppressing NF-κB activation. The findings reveal a regulatory mechanism how TSLP expression is induced in the intervertebral disc tissue and suggest a novel role of TGF-β in maintaining the homeostasis of intervertebral disc tissue. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

PMID: 23483604 [PubMed – as supplied by publisher]

[Kyphoplasty update : What are the limits – what is possible?].

By London Spine
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[Kyphoplasty update : What are the limits – what is possible?].

Unfallchirurg. 2011 Nov;114(11):1035-40

Authors: Prokop A, König B, Schultheiss M, Andresen R

Abstract
Kyphoplasty is an established procedure for the treatment of osteoporotic vertebral compression fractures. Developments in instrumentation and techniques have facilitated its use also for other localizations. In the hands of experienced practitioners smaller working cannulas and balloons have made successful treatment of high thoracic and cervical fractures and metastases possible. Balloon kyphoplasty performed for sacral insufficiency fractures in older patients plagued by chronic pain leads to marked pain reduction as well as faster weight-bearing. There are also early research results regarding the repair of tibial head defects and reinforcement with resorbable cement. These new procedures, which are currently applied by only a few surgeons, will be introduced and described in a case-specific manner.

PMID: 21909733 [PubMed – indexed for MEDLINE]