The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain.

By London Spine

The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain.

Psychopharmacology (Berl). 2008 Jan;195(4):559-68

Authors: Dong XW, Jia Y, Lu SX, Zhou X, Cohen-Williams M, Hodgson R, Li H, Priestley T

Fluphenazine is a potent antipsychotic drug used to treat schizophrenia and other psychotic symptoms. Its clinical benefit is mainly mediated by the antagonism of dopamine D2 receptors. We have recently discovered, however, that fluphenazine is also a potent sodium channel blocker, a property that may offer additional therapeutical indications, including analgesia.

PMID: 17891479 [PubMed – indexed for MEDLINE]