Neuroblastoma in an adult: case report.

By London Spine

Neuroblastoma in an adult: case report.

Rev Med Chil. 2010 Sep;138(9):1131-4

Authors: Miranda Soares PB, Quirino Filho S, Pereira DE Souza W, Ferreti Bonan PR, Martelli-Júnior H

Neuroblastoma is the most common extracranial solid malignancy in children but rarely described in adults, being 10% of all cases diagnosed after the first decade of life. We report a 23 year-old black woman with a mass at paravertebral region of T3-T5, multiple lesions in vertebral bodies and expanding skull-brain lesion at the right parietal region. Immunohistochemical analysis (negative for CD99, CD20, CD3 and desmin; and positive chromogranin, synaptophysin and NB84) confi rmed the diagnosis of neuroblastoma. The patient was submitted to 12 cycles of chemotherapy receiving VAC (vincristine/doxorubicin/cyclophosphamide) interspersed with ICE (ifosfamide/mesna/etoposide) and doxorubicin was replaced by actinomycin in the 7th cycle. She had good tolerance to this therapy, and has been clinically stable.

PMID: 21249281 [PubMed – indexed for MEDLINE]