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Tag: adolescent idiopathic scoliosis|article link|Scoliosis

SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese.

By wp_zaman

SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese.

J Hum Genet. 2012 Feb 2;

Authors: Fan YH, Song YQ, Chan D, Takahashi Y, Ikegawa S, Matsumoto M, Kou I, Cheah KS, Sham P, Cheung KM, Luk KD

Abstract
A study was conducted to validate the most significant single nucleotide polymorphism (SNP) from a genome-wide association study of Japanese adolescent idiopathic scoliosis (AIS) patients in an independent southern Chinese population. In total, 300 AIS patients fulfilled the clinical criteria and 788 controls with MRI scans of the spine were included in the replication study. We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population. The results suggest that SNP rs11190870 is significantly associated with AIS (P=9.1 × 10(-10); odds ratio=1.85; 95% confidence interval=1.52-2.25). The results of this study confirm that SNP rs11190870 is associated with AIS.Journal of Human Genetics advance online publication, 2 February 2012; doi:10.1038/jhg.2012.11.

PMID: 22301463 [PubMed – as supplied by publisher]

Infantile and adolescent idiopathic scoliosis in the same individual.

By wp_zaman

Infantile and adolescent idiopathic scoliosis in the same individual.

Acta Orthop Scand. 1977;48(5):461-5

Authors: Bjerkreim I

A patient with an infantile, resolving type of idiopathic scoliosis is presented. By the age of 10 years, 4 years after complete spontaneous correction, the girl had developed a structural, progressive idiopathic scoliosis to the opposite side.

PMID: 596142 [PubMed – indexed for MEDLINE]