Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients.

By Kamruz Zaman

Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients.

Acta Otolaryngol. 2017 Nov 21;:1-6

Authors: Carpén T, Sjöblom A, Lundberg M, Haglund C, Markkola A, Syrjänen S, Tarkkanen J, Mäkitie A, Hagström J, Mattila P

Abstract
OBJECTIVES: Oropharyngeal squamous cell carcinoma (OPSCC) is divided in two different disease entities depending on HPV involvement. We investigated differences in presenting symptoms and clinical findings in patients with HPV-positive and -negative OPSCC tumors.
METHODS: Altogether 118 consecutive patients diagnosed with primary OPSCC between 2012 and 2014 at the Helsinki University Hospital were included. HPV-status of the tumors was assessed by PCR detection of HPV DNA and immunostaining with p16-INK4a antibody.
RESULTS: Fifty-one (47.7%) of the patients had HPV-positive and 56 (52.3%) HPV-negative tumors. Forty-nine (49/51, 96.1%) of the HPV+ tumors were also p16+ showing high concordance. The most common presenting symptom among HPV+/p16+ patients was a neck mass (53.1%), whereas any sort of pain in the head and neck area was more frequently related to the HPV-/p16- (60.0%) group. HPV+/p16+ tumors had a tendency to locate in the tonsillar complex and more likely had already spread into regional lymph nodes compared with HPV-/p16- tumors. Smoking and alcohol consumption were significantly more common among HPV+/p16+ patients but also rather common among HPV-/p16- patients.
CONCLUSIONS: This analysis of symptoms and signs confirm that OPSCC can be dichotomized in two distinct disease entities as defined by HPV status.

PMID: 29161981 [PubMed – as supplied by publisher]

Necessity of admission to improve the hearing-recovery rate in idiopathic sudden sensorineural hearing loss.

By Kamruz Zaman
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Necessity of admission to improve the hearing-recovery rate in idiopathic sudden sensorineural hearing loss.

Acta Otolaryngol. 2017 Nov 13;:1-6

Authors: Kim MJ, Heo KW, Jeon PH, Lee JJ, Ho Lee J

Abstract
OBJECTIVES: The purpose of this study was to determine the prognostic potential of admission of a patient for idiopathic sudden sensorineural hearing loss (ISSNHL).
STUDY DESIGN: Retrospective clinical study.
METHODS: We conducted a retrospective study of 301 patients with ISSNHL. The patients were divided into a study (57 patients at out-patients department (OPD) based treatment, using systemic steroids and intra-tympanic (IT) steroid injection) and a control groups (301 patients at admission, using systemic steroids and IT steroid injection). We compared the success rate (15 dB cut off), Siegel’s criteria and hearing gain decibels between two groups.
RESULTS: The overall recovery rate of the OPD based treatment group (29.8%) was poor than that of the admission group (52.9%) (p = .002). The odd ratio of OPD based treatment factor was 2.035 when the OPD based treatment and poor prognostic factors were analyzed at logistic regression test (Duration of delayed treatment, 1.073; average hearing loss level, 0.972) (p = .041).
CONCLUSION: Admission must be strongly recommended when the patients with ISSNHL asked about the necessity of admission. We hypothesized that resting, getting out of their social stress, and relief of anxiety might be helpful to their hearing recoveries.

PMID: 29130359 [PubMed – as supplied by publisher]