Synchrotron-generated X-ray microplanar beams (microbeams) are characterized by peculiar biological properties such as a remarkable tissue-sparing effect in healthy tissues including the central nervous system (CNS) and, as a direct consequence, the ability to deliver extremely high doses without induction of radionecrosis. Growing experimental evidence is showing remarkable tolerance of brain and spinal cord to irradiation with microbeam arrays delivering doses up to 400 Gy with a beam width up to 0.7 mm. Submillimetric beams can be delivered following a stereotactic design bringing to the target doses in the range of hundreds of Gray without harm to the surrounding tissues. Microbeam arrays can be used to generate cortical transections or subcortical lesions, thus enabling the non-invasive modulation of brain networks. This novel microradiosurgical approach is of great interest for the treatment of a variety of brain disorders, including functional diseases such as epilepsy and movement disorders
Keywords : Animals,Brain,Brain Neoplasms,Central Nervous System,Disease Models,Animal,Dose-Response Relationship,Radiation,Humans,instrumentation,Italy,methods,Movement,Movement Disorders,Nervous System,Radiosurgery,Spinal Cord,surgery,Synchrotrons,, Microbeam,Radiosurgery,Novel,Experimental, what happens at a pain management clinic uk
Date of Publication : 2011 Oct
Authors : Romanelli P;Bravin A;
Organisation : Cyberknife Radiosurgery Center, Centro Diagnostico Italiano (CDI), Milano, Italy. radiosurgery2000@yahoo.com
Journal of Publication : Neurol Res
Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/22004705
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