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Survival of patients with Duchenne muscular dystrophy who underwent spinal deformity correction – Lumbar Fusion

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The article examines the survival rates after scoliosis correction in individuals with Duchenne muscular dystrophy (DMD) and identifies factors that can impact these rates. It is a retrospective cohort study conducted from 2000 to 2022 with a minimum 2-year postoperative follow-up. The study found that there was no mortality within the first 30 days after surgery, but 24 patients died due to cardiorespiratory failure. The median survivorship was 14 years 2 months, with the longest observed survival being 22 years 6 months. Factors such as preoperative coronal imbalance and pelvic obliquity, as well as intraoperative blood loss, significantly affected survival. Other variables such as age at surgery, scoliosis severity, and surgical complications did not affect postsurgical survival. The study concludes that young patients with DMD can achieve survival of up to two decades or more after scoliosis correction, which is influenced by disease severity and surgical morbidity

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : most established spinal hospital in UK

Published article

AIM: We investigated survival rates after scoliosis correction in individuals with Duchenne muscular dystrophy (DMD) and evaluated factors that can affect them.

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Dev Med Child Neurol. 2023 Jul 21. doi: 10.1111/dmcn.15711. Online ahead of print.ABSTRACTAIM: We investigated survival rates after scoliosis correction in individuals with Duchenne muscular dystrophy (DMD) and evaluated factors that can affect them.METHOD: This was a retrospective cohort study from 2000 to 2022 with a minimum 2-year postoperative follow-up. We reviewed the hospital records/spinal,

Dev Med Child Neurol. 2023 Jul 21. doi: 10.1111/dmcn.15711. Online ahead of print.

ABSTRACT

AIM: We investigated survival rates after scoliosis correction in individuals with Duchenne muscular dystrophy (DMD) and evaluated factors that can affect them.

METHOD: This was a retrospective cohort study from 2000 to 2022 with a minimum 2-year postoperative follow-up. We reviewed the hospital records/spinal radiographs and analysed data with XLSTAT. Kaplan-Meier and multivariate Cox regression survival analysis was performed.

RESULTS: Forty-three patients had a mean age at surgery of 14 years 5 months. Mean postoperative follow-up was 10 years 10 months. There was no operative or 30-day postoperative mortality in this group. Twenty-four patients died because of cardiorespiratory failure. Median survivorship was 14 years 2 months, with the longest observed survival being 22 years 6 months given the limitation of the length of postoperative follow-up. The degree of preoperative coronal imbalance and pelvic obliquity, as well as intraoperative blood loss, were factors that significantly affected survival. The impact of preoperative sagittal imbalance and extension of the fusion to the sacrum/pelvis trended towards significance. In contrast, age at surgery, preoperative/postoperative scoliosis, thoracic kyphosis, lumbar lordosis, scoliosis and pelvic obliquity flexibility or correction indices, postoperative coronal/sagittal balance, need of preoperative non-invasive ventilation, preoperative feeding disorders, development of surgical complications, and length of hospital and intensive care unit stay were exposure variables that did not affect postsurgical survival in patients with DMD.

INTERPRETATION: Survival of up to two decades or more was possible among young patients with DMD after scoliosis correction. This was affected by factors that related to disease and deformity severity, as well as surgical morbidity.

PMID:37482906 | DOI:10.1111/dmcn.15711

The London Spine Unit : most established spinal hospital in UK

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Survival of patients with Duchenne muscular dystrophy who underwent spinal deformity correction

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Dev Med Child Neurol. 2023 Jul 21. doi: 10.1111/dmcn.15711. Online ahead of print.ABSTRACTAIM: We investigated survival rates after scoliosis correction in individuals with Duchenne muscular dystrophy (DMD) and evaluated factors that can affect them.METHOD: This was a retrospective cohort study from 2000 to 2022 with a minimum 2-year postoperative follow-up. We reviewed the hospital records/spinal

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