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Sudden death from diffuse leptomeningeal oligodendrogliomatosis

In this paper the authors describe the rare disorder of diffuse leptomeningeal oligodendrogliomatosis in a patient with an oligodendroglioma of the cauda equina who died suddenly. Reviewing this uncommon pathological entity is important so that it can be recognized and treated appropriately. This young, otherwise healthy woman with initial symptoms of low-back pain had a mass lesion of the cauda equina. During a workup, profound refractory intracranial hypertension suddenly developed despite aggressive surgical and medical intervention. Autopsy revealed a spinal cord oligodendroglioma with diffuse leptomeningeal oligodendrogliomatosis of the brain and spinal cord. Given the unforeseen outcome in this patient, this entity, although rare, should be considered in patients with similar presentations and addressed early to prevent similar outcomes. A review of the details of this case as well as the literature is presented below

Keywords : Adult,Autopsy,Brain,Cauda Equina,Death,Sudden,Fatal Outcome,Female,Humans,Hypertension,Intracranial Hypertension,Low Back Pain,Magnetic Resonance Imaging,Meningeal Neoplasms,Neoplasm Invasiveness,Neurosurgery,Oligodendroglioma,Pain,pathology,Patients,Severity of Illness Index,Spinal Cord,Spinal Cord Neoplasms,surgery,Tomography,X-Ray Computed,Universities,, Death,From,Diffuse,Leptomeningeal,Oligodendrogliomatosis, brief pain inventory short form

Date of Publication : 2011 Dec

Authors : Reynolds RM;Boswell E;Hulette CM;Cummings TJ;Haglund MM;Boswell E;Hulette CM;Cumm Ings TJ;Haglund MM;

Organisation : Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA. [email protected]

Journal of Publication : J Neurosurg Spine

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21888480

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