Profitable cisplatin-etoposide chemotherapy-based remedy of a main small cell neuroendocrine carcinoma of the tonsil with a number of metastases: a case report.
Onco Targets Ther. 2018;11:5391-5395
Authors: Wang X, Chen Q, Meng J
Extrapulmonary small cell neuroendocrine carcinoma (SNEC) is an especially uncommon and extremely malignant tumor with a poor prognosis. A number of metastases of SNEC are much more uncommon, and sufferers with regionally superior and metastatic illness typically face a poor consequence. Up to now, just a few instances of SNEC have been reported. Right here, we describe a uncommon case of a 70-year-old feminine affected person with SNEC of the tonsil who introduced with a number of metastases and had achieved a whole response (CR) of the first lesion and cervical lymph nodes for greater than 1 yr after receiving palliative chemotherapy. Initially, the affected person introduced with a 2-month historical past of throat ache. Magnetic resonance imaging and computed tomography revealed a delicate mass with average enhancement on the left tonsil, which was confirmed by incisional aspiration biopsy. She was moreover despatched for a positron emission tomography scan to guage small metastases within the left cervical lymph node, proper lung, a number of mediastinal lymph nodes, and the fourth lumbar (L4) vertebra physique metastases. Histopathological examination of the SNEC confirmed a nested, typical endocrine look with small spherical cells containing ovoid-shaped nuclei and excessive mitotic exercise. Immunohistochemically, the tumor cells had been constructive for cytokeratin eight/18+, synaptophysin+, CD56+, and Ki-67 (<50%). The affected person acquired 6 cycles of cisplatin mixed with etoposide and was subsequently positioned below shut statement (<12 months). Up to now, she has achieved a CR of the first lesion and cervical lymph nodes. In abstract, we’ve described a case of profitable remedy after chemotherapy for SNEC and have elucidated skilled information concerning the related elements of SNEC.
PMID: 30214244 [PubMed]