19 Harley St, London, W1G 9QJ, UK

Stereotactic radiotherapy in the liver hilum. Basis for future studies

BACKGROUND: A basis for future trials with stereotactic body radiotherapy (SBRT) for tumors of the liver hilum should be established. Thus, dosage concepts, planning processes, and dose constraints as well as technical innovations are summarized in this contribution. METHODS: On the background of our own data, the current literature was reviewed. The use of SBRT in the most common tumors of the liver hilum (pancreatic cancer and Klatskin tumors) was investigated. Dose constraints were calculated in 2 Gy standard fractionation doses. RESULTS: A total of 8 pilot or phase I/II studies about SBRT in the liver hilum were identified. In recent years, the SBRT technique has developed very quickly from classical stereotactic body frame radiotherapy to IGRT techniques including gating and tracking systems. In the studies using classical body frame technique, patients experienced considerable toxicities (duodenal ulcer/perforation) as compared to tolerable side effects in IGRT studies (<10% grade 3 and 4 toxicities). Dose constraints for duodenum, liver, kidneys, colon, and spinal cord were derived from the investigated studies. Survival and local tumor control data are very heterogeneous: median survival in these patients with locally advanced pancreatic or Klatskin tumors ranges between 5 and 32 months. Excellent local tumor control rates of about 80% over 24 months were achieved using SBRT. CONCLUSION: Despite a few negative results, SBRT seems to be a promising technique in the treatment of tumors of the liver hilum. Highest precision in diagnostics, positioning, and irradiation as well as strict dose constraints should be applied to keep target volumes as small as possible and side effects tolerable Keywords : Bile Duct Neoplasms,Clinical Trials,Phase I as Topic,Clinical Trials,Phase II as Topic,Colon,etiology,Follow-Up Studies,Germany,Hepatic Duct,Common,Kidney,Klatskin Tumor,Liver,methods,mortality,Pancreatic Neoplasms,pathology,Patients,Pilot Projects,Postoperative Complications,Radiosurgery,radiotherapy,Spinal Cord,surgery,Survival Rate,toxicity,trends,Universities,, Radiotherapy,Liver,Hilum, nerve pain groin

Date of Publication : 2012 Jan

Authors : Zamboglou C;Messmer MB;Becker G;Momm F;

Organisation : Department of Radiation Oncology, University Hospital Freiburg, Robert-Koch-Str. 3, 79106, Freiburg, Germany

Journal of Publication : Strahlenther Onkol

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/22194027

The London Spine Unit : Harley Street UK. Specialists in Cutting Edge Technologies for Spinal Surgery

Make an Appointment 

Trustpilot Reviews
Doctify Reviews
Top Doctor Reviews

Stereotactic radiotherapy in the liver hilum Basis for future studies | Touch tens machine

What our patients say ...

Consultant Spine Surgeon
Consultant Spine Surgeon
Consultant Spine Surgeon

This surgical technique consists of a percutaneous approach for the treatment of small to medium size hernias of the intervertebral disc by laser energy. The main objective is to reduce the intradiscal pressure in the nucleus pulposus

Laser Disc Surgery can be performed under local anaesthetic as a day case at our centre on the prestigious Harley Street.
What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

treatment of all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

If you have any emergency Doctor’s need, simply call our 24 hour emergency

Your personal case manager will ensure that you receive the best possible care.

Call Now 

+44 844 589 2020
+44 203 973 8810