Splenic hamartoma with weird stromal cells: a case report and literature overview.
Diagn Pathol. 2018 Jan 22;13(1):eight
Authors: Cheng N, Chen J, Pan Y, Jiang Y, Zhou J, Shao C
Summary
BACKGROUND: Splenic hamartoma is a uncommon benign vascular proliferative lesion composed of unorganized sinusoid-like channels lined with plump or flat endothelial cells and characterised by a CD8-positive immunophenotype of the liner cells. Scattered weird stromal cells might be present in some splenic hamartomas. The presence of splenic hamartoma with weird stromal cells is extraordinarily uncommon and these weird cells make it doable to be thought to be a malignancy. Recognition of this uncommon histologic variant will assist to keep away from diagnostic confusion and overtreatment of this benign entity.
CASE PRESENTATION: We report a case of a 40-year-old man with occasional left-sided waist again ache. A splenic space-occupying lesion was detected by ultrasound and magnetic resonance imaging. Microscopically weird massive cells have been scattered all through the splenic hamartoma. The cells exhibited atypical nuclei, scarcely seen cytoplasm, and vesicular chromatin, and they didn’t type expansile clusters and lacked mitotic exercise. An immunohistochemical panel was carried out. The weird cells strongly expressed vimentin, and the Ki-67 index was very low. The lesion was identified as a splenic hamartoma with weird stromal cells.
CONCLUSIONS: To the most effective of our data, that is the primary systematic overview on a splenic hamartoma with weird stromal cells; solely six instances have been described within the literature. Correct identification is necessary to safe enough remedy.
PMID: 29378604 [PubMed – in process]