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Spinal tuberculosis in post-liver transplantation patients: case reports

Recipients of solid organ transplantation are, because of immunosuppressive therapy, disposed to opportunistic infections including tuberculosis (TB). Spinal TB is a rare complication after transplantation but it is serious with high mortality. We report 3 cases of spinal TB in Chinese recipients of orthotopic liver transplant whose first complaint was back pain. These 3 cases were diagnosed by magnetic resonance imaging and percutaneous biopsy. After treatment with isoniazid, rifampicin, streptomycin, and ethambutol for >1 year, symptoms of 2 patients improved noticeably, but 1 patient died of liver failure and severe mixed pulmonary infection. Diagnosis and treatment regimens of spinal TB are discussed

Keywords : Adult,adverse effects,Aged,Anti-Bacterial Agents,Antitubercular Agents,Back Pain,Biopsy,China,diagnosis,drug effects,Drug Resistance,Multiple,Bacterial,drug therapy,etiology,Fatal Outcome,Female,Humans,Immunosuppression,isolation & purification,Isoniazid,Liver,Liver Transplantation,Magnetic Resonance Imaging,Male,Middle Aged,mortality,Mycobacterium tuberculosis,Opportunistic Infections,Pain,pathology,pharmacology,Postoperative Complications,Spinal Cord,Streptomycin,therapeutic use,therapy,transplantation,Tuberculosis,Tuberculosis,Spinal,, Tuberculosis,Postliver,Transplantation,Patients, botox for legs

Date of Publication : 2010 Apr

Authors : Lou XF;Wu RH;Xu SZ;Lin XJ;

Organisation : Department of Orthopedics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Journal of Publication : Transpl Infect Dis

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/19929883

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