Spinal Rosai-Dorfman illness: case report and literature assessment.
Eur Backbone J. 2017 Could;26(Suppl 1):117-127
Authors: Xu H, Zhang F, Lu F, Jiang J
OBJECTIVE: Sinus histiocytosis with huge lymphadenopathy or Rosai-Dorfman illness (RDD) is a uncommon benign illness of doubtful etiology that arises predominantly in lymph nodes with generalized fever and malaise. Remoted intraspinal involvement has its distinctive traits. The aim of this research is to current the most important collection of circumstances within the spinal Rosai-Dorfman illness literature to extend familiarity with its clinicopathologic options, analysis, and therapy of RDD from backbone.
METHODS: We current the case of a 34-year-old man who offered with paraplegia secondary to an remoted thoracic vertebral lesion. On bodily examination, the affected person displayed progressive weak spot and tendon hyperreflexia of the decrease limbs. After a completely part, signs of the affected person have been clearly relieved and the affected person remained asymptomatic and no indicators of recurrences have been noticed after follow-up for five months. We additionally retrospectively analyzed 60 circumstances of sufferers with spinal RDD printed in English since 1969. Scientific date, histopathology, and radiological function have been retrospectively analyzed.
RESULTS: Spinal RDD ought to not be thought of uncommon and it might occupy an more and more outstanding place within the checklist of differential diagnoses for intraspinal lesions. Solely elaborate histopathology was diagnostic for RDD. Many of the sufferers have been surgically handled and marked enhancements have been noticed of their medical situations.
CONCLUSIONS: RDD with spinal involvement is unusual and it’s challengeable in making a sure analysis. Histopathologic traits and immunohistochemical findings are thought of as the important thing factors for the analysis of this illness. The optimum therapy stays controversial, and extra efforts ought to be targeted on the investigation of etiology and adjuvant remedy for relapsing circumstances or subresected lesions.
PMID: 28168342 [PubMed – indexed for MEDLINE]