Cranium base or cervical vertebral osteomyelitis following chemoradiotherapy for pharyngeal carcinoma: A severe however treatable complication.
Clin Transl Radiat Oncol. 2018 Jan;eight:40-44
Authors: Lalani N, Huang SH, Rotstein C, Yu E, Irish J, O’Sullivan B
Osteomyelitis, an infection of the bone and marrow, following excessive dose (chemo-)radiotherapy for head and neck most cancers is rare and barely seen within the cervical backbone or temporal bone. On account of its proximity to crucial buildings, osteomyelitis within the latter areas may carry probably necessary penalties. Moreover, involvement close to the cranium base (e.g. temporal bone and excessive cervical vertebrae) presents distinctive challenges in prognosis (particularly within the differentiation from illness recurrence) and therapy, making early detection and well timed intervention crucial. On this report, we describe two circumstances of osteomyelitis, one involving the temporal bone and the opposite affecting the 2nd and third cervical vertebrae, recognized and handled with good end result within the setting of definitive chemoradiotherapy for regionally superior pharyngeal carcinomas. We advise that for brand spanking new or evolving post-radiotherapy osseous adjustments in areas which have acquired a excessive dose of radiotherapy, related to sudden and deteriorating spinal signs reminiscent of ache and spasm, radiation-related osteomyelitis needs to be thought-about within the differential prognosis from tumor development. Well timed referral to a surgical oncologist and infectious illnesses specialist is paramount in reaching passable scientific outcomes.
PMID: 29594240 [PubMed]