Skeletal Fluorosis Due To Inhalation Abuse of a Difluoroethane-Containing Pc Cleaner.
J Bone Miner Res. 2017 Jan;32(1):188-195
Authors: Tucci JR, Whitford GM, McAlister WH, Novack DV, Mumm S, Keaveny TM, Whyte MP
Skeletal fluorosis (SF) is endemic in lots of nations and hundreds of thousands of individuals are affected worldwide, whereas in the US SF is uncommon with occasional descriptions of distinctive circumstances. We report a 28-year-old American man who was wholesome till 2 years earlier when he progressively skilled problem strolling and an irregular gait, left hip ache, lack of mobility in his proper wrist and forearm, and progressive deformities together with enlargement of the digits of each fingers. Twin-energy X-ray absorptiometry (DXA) of his lumbar backbone, femoral neck, complete hip, and the one-third forearm revealed bone mineral density (BMD) Z-scores of +6.2, +four.eight, +three.Zero, and -Zero.2, respectively. Serum, urine, and bone fluoride ranges had been all elevated and finally defined by power sniffing abuse of a pc cleaner containing 1,1-difluoroethane. Our findings replicate SF because of the uncommon explanation for inhalation abuse of difluoroethane. As a result of this follow appears widespread, notably within the younger, there could also be many extra such circumstances. © 2016 American Society for Bone and Mineral Analysis.
PMID: 27449958 [PubMed – indexed for MEDLINE]