Quick course accelerated radiation remedy (SHARON) in palliative therapy of superior strong most cancers in older sufferers: A pooled evaluation.
J Geriatr Oncol. 2018 Feb 01;:
Authors: Farina E, Capuccini J, Macchia G, Caravatta L, Nguyen NP, Cammelli S, Zanirato Rambaldi G, Cilla S, Wondemagegnhu T, Uddin AFMK, Sumon MA, Genovesi D, Buwenge M, Cellini F, Valentini V, Deodato F, Morganti AG
OBJECTIVES: To judge the efficacy and security of a conformal Quick Course Accelerated Radiation remedy (SHARON) for symptomatic palliation of regionally superior or metastatic cancers in older sufferers.
MATERIALS AND METHODS: It is a pooled evaluation on sufferers aged ?80 years chosen between topics enrolled in three part I-II research on a brief course palliative therapy of superior or metastatic most cancers. The first endpoint was to judge the signs response fee produced by accelerated radiotherapy delivered in four complete fractions in twice a day. Whole dose ranged between 14 Gy and 20 Gy whereas dose/fraction between three.5 and 5 Gy.
RESULTS: A complete of 48 sufferers have been included on this evaluation. Twenty-six sufferers (54.2%) had superior main or metastatic head and neck tumors, 11 (22.9%) regionally superior or metastatic thoracic cancers, 11 (22.9%) difficult bone metastases. Nearly all of sufferers introduced ache (60.four%). With a median follow-up time of 5.5 months, no G4 acute and late toxicities have been recorded. The general palliative response fee was 91.7% with a median period of palliation of four months.
CONCLUSION: Quick course accelerated radiotherapy in regionally superior or metastatic cancers is efficient by way of symptom reduction and properly tolerated even in older sufferers.
PMID: 29398455 [PubMed – as supplied by publisher]