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Seronegative neuromyelitis optica spectrum dysfunction sufferers recognized utilizing new diagnostic standards.

Mult Scler. 2016 09;22(10):1371-5

Authors: Uzawa A, Mori M, Uchida T, Masuda H, Ohtani R, Kuwabara S

Summary
BACKGROUND: Not too long ago, new diagnostic standards for neuromyelitis optica spectrum problems (NMOSD) have been revealed.
OBJECTIVE: Our main intention was to guage the usefulness of the brand new diagnostic standards in anti-aquaporin four (AQP4) antibody-negative circumstances.
METHODS: Consecutive 471 sufferers whose anti-AQP4 antibody was measured at Chiba College have been reviewed.
RESULTS: 4 anti-AQP4 antibody negative-patients, who fulfilled the brand new diagnostic standards for NMOSD however not 2006 diagnostic standards for neuromyelitis optica (NMO), have been recognized. They confirmed excessive cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein ranges, an absence of oligoclonal bands and/or cloud-like enhancement on magnetic resonance imaging, that are appropriate findings for NMO.
CONCLUSION: The brand new diagnostic standards are clinically helpful in seronegative NMOSD.

PMID: 26552730 [PubMed – indexed for MEDLINE]