SCN5A Genetic Polymorphisms Related With Elevated Defibrillator Shocks in Brugada Syndrome.
J Am Coronary heart Assoc. 2017 Jun 05;6(6):
Authors: Makarawate P, Chaosuwannakit N, Vannaprasaht S, Sahasthas D, Koo SH, Lee EJD, Tassaneeyakul W, Barajas-Martinez H, Hu D, Sawanyawisuth Okay
BACKGROUND: Brugada syndrome (BrS) is an inherited major arrhythmia dysfunction resulting in sudden cardiac arrest. SCN5A, encoding the ?-subunit of the cardiac sodium channel (Nav1.5), is the commonest pathogenic gene of BrS. An implantable cardioverter defibrillator (ICD) is the usual remedy for secondary prevention. This examine aimed to judge affiliation of the SCN5A variant with this cardiac conduction disturbance and acceptable ICD shock remedy in Thai symptomatic BrS sufferers with ICD implants.
METHODS AND RESULTS: Symptomatic BrS sufferers identified at college hospital had been enrolled from 2008 to 2011. The first end result of the examine was an acceptable ICD shock outlined as having non-pacing-associated ICD shock after the prevalence of ventricular tachycardia or ventricular fibrillation. Associations between SCN5A polymorphisms, cardiac conduction disturbance, and potential confounding components related to acceptable ICD shock remedy had been analyzed. All 40 symptomatic BrS sufferers (median age, 43 years) with ICD implantations had been adopted for 24 months. There have been 16 sufferers (40%) who had the suitable ICD shock remedy after ICD remedy. An impartial issue related to acceptable ICD shock remedy was SCN5A-R1193Q with an adjusted hazard ratio of 10.550 (95% CI, 1.631-68.232).
CONCLUSIONS: SCN5A-R1193Q is related to cardiac conduction disturbances. It could be a genetic marker related to ventricular arrhythmia resulting in acceptable ICD shock remedy in symptomatic BrS sufferers with ICD remedy. Due to the small pattern measurement of examine inhabitants and the suitable ICD shock end result, additional giant research are wanted to verify the outcomes of this examine.
PMID: 28584071 [PubMed – indexed for MEDLINE]