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Sarcoidosis and spondyloarthritis: A coincidence or widespread etiopathogenesis?
Caspian J Intern Med. 2018;9(1):100-103
Authors: Wafa H, Saoussen M, Dhia Okay, Imen Z, Montacer KM
Summary
Background: Sarcoidosis is a multisystem granulomatous illness. Co-existence with spondyloarthritis (SA) has been extra described as an opposed impact of anti-TNF ? remedy than an affiliation. We report herein a case of a typical sarcoidosis confirmed by histological proofs and a sophisticated SA with a bamboo column.
Case Presentation: A 48-years-old girl introduced with inflammatory again ache for five years and ankle swelling for 1 12 months. On bodily examination, she had an exaggerated dorsal kyphosis and disappearance of lumbar lordosis with limitation in movement of the cervical and lumbar backbone. Laboratory exams didn’t present an inflammatory syndrome or hypercalcemia. Plain radiographies of the backbone and pelvic revealed a triple ray look with sacroiliitis grade four. Chest radiography and CT confirmed the presence of bilateral hilar lymph nodes and parenchymal nodes. Bronchoscopy and biopsies had been carried out displaying non-calcified granulomatous response with out cell necrosis. The analysis of SA was carried out based mostly on 9 factors of Amor standards related to pulmonary sarcoidosis. She was handled with 15 mg per week of methotrexate and 1mg/kg/day of prednisone for pulmonary illness with good outcomes.
Conclusions: Sarcoidosis could also be related to SA moreover paradoxical drug impact. The identical physio pathological pathways mediate by TNF ? are arguments for affiliation than hazardous coincidence.
PMID: 29387328 [PubMed]